Publication
Controlled in Vitro Release of Levodopa from Sodium Alginate Membranes
| datacite.subject.sdg | 03:Saúde de Qualidade | |
| datacite.subject.sdg | 09:Indústria, Inovação e Infraestruturas | |
| datacite.subject.sdg | 12:Produção e Consumo Sustentáveis | |
| dc.contributor.author | Franco, Margarida | |
| dc.contributor.author | Biscaia, Sara | |
| dc.contributor.author | Viana, Tânia | |
| dc.contributor.author | Alves, Nuno | |
| dc.contributor.author | Morouço, Pedro | |
| dc.date.accessioned | 2025-05-28T14:19:55Z | |
| dc.date.available | 2025-05-28T14:19:55Z | |
| dc.date.issued | 2016-12-01 | |
| dc.description.abstract | Levodopa (LD) plays a central role in Parkinson’s Disease therapeutics. In this study, we aimed to encapsulate LD in sodium alginate (SA) membranes, and to study its dissolution profiles. Two types of SA membranes, loaded with two different amounts of LD were prepared and compared (M1: 85 mg per 50 ml SA/LD; M2: 127.5 mg per 75 ml SA/LD); membranes production followed a solvent-casting methodology. Calcium chloride was used as a crosslinking agent. LD solubility tests were performed to predict sink conditions required for complete drug dissolution. LD dissolution assays were carried out and UV spectrophotometry was used for cumulative release percentage determination. The obtained data were mathematically evaluated and fitted into mathematical dependent models; the difference factor (f1), the similarity factor (f2) and other parameters like dissolution efficiency (DE) were also used. No differences in the dissolution profiles of both membranes were noticed. Thus, increasing the amount of LD, but keeping the same concentration, led to a similar controlled release. The membranes presented in this work are expected to be a promising contribution in the development of a new controlled drug delivery system for LD administration. | eng |
| dc.description.sponsorship | This research was funded by the Portuguese Government – Foundation for Science and Technology (UID/Multi/04044/2013). | |
| dc.identifier.citation | Franco, Margarida & Biscaia, Sara & Viana, Tânia & Alves, Nuno & Morouço, Pedro. (2016). Controlled in Vitro Release of Levodopa from Sodium Alginate Membranes. International Journal of Drug Delivery Technology. 6. 116-122. 10.25258/ijddt.v6i4.8898. | |
| dc.identifier.doi | 10.25258/ijddt.v6i4.8898 | |
| dc.identifier.issn | 0975-4415 | |
| dc.identifier.uri | http://hdl.handle.net/10400.8/13019 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | Dr. Yashwant Research Labs Pvt. Ltd. | |
| dc.relation | Centre for Rapid and Sustainable Product Development | |
| dc.relation.ispartof | International Journal of Drug Delivery Technology | |
| dc.relation.ispartofseries | 116; 122 | |
| dc.rights.uri | N/A | |
| dc.subject | Parkinson’s disease | |
| dc.subject | Controlled delivery | |
| dc.subject | Dissolution assays | |
| dc.subject | Drug release kinetics | |
| dc.subject | Mathematical model fitting | |
| dc.title | Controlled in Vitro Release of Levodopa from Sodium Alginate Membranes | eng |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | Centre for Rapid and Sustainable Product Development | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04044%2F2013/PT | |
| oaire.citation.issue | 4 | |
| oaire.citation.title | International Journal of Drug Delivery Technology | |
| oaire.citation.volume | 6 | |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |
| person.familyName | Franco | |
| person.familyName | Biscaia | |
| person.familyName | Alves | |
| person.familyName | Morouço | |
| person.givenName | Margarida | |
| person.givenName | Sara | |
| person.givenName | Nuno | |
| person.givenName | Pedro | |
| person.identifier | 2300879 | |
| person.identifier | 452149 | |
| person.identifier | 435983 | |
| person.identifier.ciencia-id | 3818-262C-0441 | |
| person.identifier.ciencia-id | 0516-3C03-93F3 | |
| person.identifier.ciencia-id | 311E-1559-8F6C | |
| person.identifier.ciencia-id | F619-3996-742A | |
| person.identifier.orcid | 0000-0001-9659-7646 | |
| person.identifier.orcid | 0000-0002-2609-6878 | |
| person.identifier.orcid | 0000-0002-5016-0868 | |
| person.identifier.orcid | 0000-0002-5956-9790 | |
| person.identifier.rid | O-1146-2013 | |
| person.identifier.rid | N-4073-2013 | |
| person.identifier.rid | K-9545-2013 | |
| person.identifier.scopus-author-id | 55885992900 | |
| person.identifier.scopus-author-id | 55867382400 | |
| person.identifier.scopus-author-id | 7006403383 | |
| person.identifier.scopus-author-id | 24339135400 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
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