Publication
Electrospun PEDOT-Based Meshes for Skin Regeneration
| datacite.subject.fos | Engenharia e Tecnologia | |
| datacite.subject.sdg | 09:Indústria, Inovação e Infraestruturas | |
| dc.contributor.author | Alves, Alexandra I. F. | |
| dc.contributor.author | Alves, Nuno M. | |
| dc.contributor.author | Dias, Juliana | |
| dc.date.accessioned | 2025-09-18T14:26:17Z | |
| dc.date.available | 2025-09-18T14:26:17Z | |
| dc.date.issued | 2025-08-15 | |
| dc.description | Article number - 2227 | |
| dc.description.abstract | The application of conductive polymers in wound dressings presents great potential for accelerated wound healing since their high electrical conductivity and biocompatibility facilitate the delivery of external electrical stimuli to cells and tissues, promoting cell differentiation and proliferation. Electrospinning is a very straightforward method for the preparation of polymeric wound dressings capable of mimicking the extracellular matrix of skin, promoting hemostasis, absorbing wound exudate, allowing atmospheric oxygen permeation and maintaining an appropriately moist environment. In this work, in situ chemically polymerized poly(3,4-ethylenedioxythiophene) (PEDOT) was achieved through hyaluronic acid-doping. The synthesized PEDOT was used for the production of conductive and biodegradable chitosan (CS)/gelatin (GEL)/PEDOT electrospun meshes. Additionally, the randomly aligned meshes were crosslinked with a 1,4-butanediol diglycidyl ether and their physicochemical and mechanical properties were investigated. The results show that the incorporation of a conductive polymer led to an increase in conductivity of the solution, density and fiber diameter that influenced porosity, water uptake, and dissolvability and biodegradability of the meshes, while maintaining appropriate water vapor permeation values. Due to their intrinsic similarity to the extracellular matrix and cell-binding sequences, CS/GEL/PEDOT electrospun nanofibrous meshes show potential as conductive nanofibrous structures for electrostimulated wound dressings in skin tissue engineering applications. | eng |
| dc.description.sponsorship | This study was supported by the Fundação para a Ciência e a Tecnologia (FCT) through the Strategic Projects granted to CDRSP: UIDB/04044/2020;(https://doi.org/10.54499/UIDB/04044/2020), UIDP/04044/2020 (https://doi.org/10.54499/UIDP/04044/2020), to the Associate Laboratory ARISE (LA/P/0112/2020) and PTCentroDiH project (03/C16-i03/2022–768); and the funding to Juliana Dias (10.54499/CEECINST/00060/2021/CP2902/CT0005). This study was also supported by INOV.AM—Inovação em Fabricação Aditiva, 02-C05-i01.01-2022 and Nanofilm (CENTRO2030-FEDER-01469100). | |
| dc.identifier.citation | Alves, A.I.F.; Alves, N.M.; R. Dias, J. Electrospun PEDOT-Based Meshes for Skin Regeneration. Polymers 2025, 17, 2227. https:// doi.org/10.3390/polym17162227 | |
| dc.identifier.doi | 10.3390/polym17162227 | |
| dc.identifier.issn | 2073-4360 | |
| dc.identifier.uri | http://hdl.handle.net/10400.8/14085 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | MDPI | |
| dc.relation | Centre for Rapid and Sustainable Product Development | |
| dc.relation | Advanced Production and Intelligent Systems | |
| dc.relation.hasversion | https://www.mdpi.com/2073-4360/17/16/2227 | |
| dc.relation.ispartof | Polymers | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | In situ chemical polymerization | |
| dc.subject | PEDOT | |
| dc.subject | Wound dressing | |
| dc.subject | Conductive electrospun fibers | |
| dc.subject | Skin regeneration | |
| dc.title | Electrospun PEDOT-Based Meshes for Skin Regeneration | eng |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | Centre for Rapid and Sustainable Product Development | |
| oaire.awardTitle | Advanced Production and Intelligent Systems | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04044%2F2020/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0112%2F2020/PT | |
| oaire.citation.issue | 16 | |
| oaire.citation.title | Polymers | |
| oaire.citation.volume | 17 | |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |
| person.familyName | Alves | |
| person.familyName | Dias | |
| person.givenName | Nuno | |
| person.givenName | Juliana | |
| person.identifier | 452149 | |
| person.identifier | 633669 | |
| person.identifier.ciencia-id | 311E-1559-8F6C | |
| person.identifier.ciencia-id | 0612-D971-F00D | |
| person.identifier.orcid | 0000-0002-5016-0868 | |
| person.identifier.orcid | 0000-0002-7079-1069 | |
| person.identifier.rid | N-4073-2013 | |
| person.identifier.rid | A-6086-2014 | |
| person.identifier.scopus-author-id | 7006403383 | |
| person.identifier.scopus-author-id | 55749822200 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
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