Repository logo
 
Publication

Bio-inspired polymeric iron-doped hydroxyapatite microspheres as a tunable carrier of rhBMP-2

2020-08-22Journal article Open access
Simple item page
dc.contributor.authorPatrício, Tatiana Marisa Fernandes
dc.contributor.authorMumcuoglu, Didem
dc.contributor.authorMontesi, Monica
dc.contributor.authorPanseri, Silvia
dc.contributor.authorWitte-Bouma, Janneke
dc.contributor.authorGarcia, Shorouk Fahmy
dc.contributor.authorSandri, Monica
dc.contributor.authorTampieri, Anna
dc.contributor.authorFarrell, Eric
dc.contributor.authorSprio, Simone
dc.date.accessioned2023-03-20T15:07:12Z
dc.date.available2023-03-20T15:07:12Z
dc.date.issued2020-08-22
dc.description.abstractHybrid superparamagnetic microspheres with bone-like composition, previously developed by a bio-inspired assembling/mineralization process, are evaluated for their ability to uptake and deliver recombinant human bone morphogenetic protein-2 (rhBMP-2) in therapeutically-relevant doses along with prolonged release pro- files. The comparison with hybrid non-magnetic and with non-mineralized microspheres highlights the role of nanocrystalline, nanosize mineral phases when they exhibit surface charged groups enabling the chemical linking with the growth factor and thus moderating the release kinetics. All the microspheres show excellent osteogenic ability with human mesenchymal stem cells whereas the hybrid mineralized ones show a slow and sustained release of rhBMP-2 along 14 days of soaking into cell culture medium with substantially bioactive effect, as reported by assay with C2C12 BRE-Luc cell line. It is also shown that the release extent can be modulated by the application of pulsed electromagnetic field, thus showing the potential of remote controlling the bioactivity of the new micro-devices which is promising for future application of hybrid biomimetic mi- crospheres in precisely designed and personalized therapies.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationTatiana M. Fernandes Patrício, Didem Mumcuoglu, Monica Montesi, Silvia Panseri, Janneke Witte-Bouma, Shorouk Fahmy Garcia, Monica Sandri, Anna Tampieri, Eric Farrell, Simone Sprio, Bio-inspired polymeric iron-doped hydroxyapatite microspheres as a tunable carrier of rhBMP-2, Materials Science and Engineering: C, Volume 119, 2021, 111410, ISSN 0928-4931, https://doi.org/10.1016/j.msec.2020.111410pt_PT
dc.identifier.doi10.1016/j.msec.2020.111410pt_PT
dc.identifier.issn1873-0191
dc.identifier.urihttp://hdl.handle.net/10400.8/8265
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherScienceDirectpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBone regenerationpt_PT
dc.subjectPulsed electromagnetic fieldpt_PT
dc.subjectSustained releasept_PT
dc.subjectOsteogenesispt_PT
dc.subjectHybrid superparamagnetic microspherespt_PT
dc.subjectrhBMP-2pt_PT
dc.titleBio-inspired polymeric iron-doped hydroxyapatite microspheres as a tunable carrier of rhBMP-2pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleMaterials Science and Engineering: Cpt_PT
oaire.citation.volume119pt_PT
person.familyNameFernandes Patrício
person.givenNameTatiana Marisa
person.identifierL-2781-2015
person.identifier.ciencia-idEF1C-430E-9F29
person.identifier.orcid0000-0003-0672-9014
person.identifier.scopus-author-id55749853300
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationc256ec7c-9a07-42d9-84a2-6885b5392a00
relation.isAuthorOfPublication.latestForDiscoveryc256ec7c-9a07-42d9-84a2-6885b5392a00

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
1-s2.0-S0928493120333282-main.pdf
Size:
9.91 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.32 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CDRsp - Artigos em revistas internacionais