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Superparamagnetic hybrid microspheres affecting osteoblasts behaviour

2018-11-14Journal article Open access
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dc.contributor.authorFernandes Patrício, Tatiana Marisa
dc.contributor.authorPanseri, Silvia
dc.contributor.authorMontesi, Monica
dc.contributor.authorIafisco, Michele
dc.contributor.authorSandri, Monica
dc.contributor.authorTampieri, Anna
dc.contributor.authorSprio, Simone
dc.date.accessioned2023-05-25T14:25:31Z
dc.date.available2023-05-25T14:25:31Z
dc.date.issued2018-11-14
dc.description.abstractThe present work describes biomimetic hybrid microspheres made of collagen type I-like peptide matrix (RCP) mineralised with Fe2+/Fe3+ doping hydroxyapatite (RCPFeHA) by a bio-inspired process. Superparamagnetic RCPFeHA microspheres are obtained by emulsification of the hybrid slurries in the presence of citrate ions, to achieve a biomimetic surface functionalisation improving the bioactivity and the dispersion ability in cell culture medium. A biological in vitro study correlates the osteoblast cells behaviour to calcium and iron ions released by the hybrid microspheres in culture media mimicking physiological or inflammatory environment, evidencing a clear triggering of cell activity and bio-resorption ability. In presence of the microspheres, the osteoblast cells maintain their typical morphology and no cell damage were detected, whereas also showing up-regulation of osteogenic markers. The ability of the hybrid microspheres to undergo bio-resorption and release bioactive ions in response to different environmental stimuli without harmful effects opens new perspectives in bone regeneration, as magnetically active bone substitute with potential ability of drug carrier and smart response in the presence of inflammatory states.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationTatiana M. Fernandes Patrício, Silvia Panseri, Monica Montesi, Michele Iafisco, Monica Sandri, Anna Tampieri, Simone Sprio, Superparamagnetic hybrid microspheres affecting osteoblasts behaviour, Materials Science and Engineering: C, Volume 96, 2019, Pages 234-247, ISSN 0928-4931, https://doi.org/10.1016/j.msec.2018.11.014pt_PT
dc.identifier.doi10.1016/j.msec.2018.11.014pt_PT
dc.identifier.issn1873-0191
dc.identifier.urihttp://hdl.handle.net/10400.8/8517
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherScienceDirectpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S092849311830184X?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectBone tissue engineeringpt_PT
dc.subjectCell behaviourpt_PT
dc.subjectIron-substituted apatiteIons releasept_PT
dc.subjectBio-inspired mineralisationpt_PT
dc.subjectHybrid microspherespt_PT
dc.titleSuperparamagnetic hybrid microspheres affecting osteoblasts behaviourpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage247pt_PT
oaire.citation.startPage234pt_PT
oaire.citation.titleMaterials Science and Engineering: Cpt_PT
oaire.citation.volume96pt_PT
person.familyNameFernandes Patrício
person.givenNameTatiana Marisa
person.identifierL-2781-2015
person.identifier.ciencia-idEF1C-430E-9F29
person.identifier.orcid0000-0003-0672-9014
person.identifier.scopus-author-id55749853300
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationc256ec7c-9a07-42d9-84a2-6885b5392a00
relation.isAuthorOfPublication.latestForDiscoveryc256ec7c-9a07-42d9-84a2-6885b5392a00

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