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PEDOT:PSS-coated polybenzimidazole electroconductive nanofibers for biomedical applications

2021-08-19Journal article Open access
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dc.contributor.authorSordini, Laura
dc.contributor.authorSilva, João C.
dc.contributor.authorGarrudo, Fábio F. F.
dc.contributor.authorRodrigues, Carlos A. V.
dc.contributor.authorMarques, Ana C.
dc.contributor.authorLinhardt, Robert J.
dc.contributor.authorCabral, Joaquim S. M.
dc.contributor.authorMorgado, Jorge
dc.contributor.authorFerreira, Frederico Castelo
dc.date.accessioned2023-03-31T11:16:14Z
dc.date.available2023-03-31T11:16:14Z
dc.date.issued2021-08-19
dc.description.abstractBioelectricity drives several processes in the human body. The development of new materials that can deliver electrical stimuli is gaining increasing attention in the field of tissue engineering. In this work, novel, highly electrically conductive nanofibers made of poly [2,20 - m-(phenylene)-5,50 -bibenzimidazole] (PBI) have been manufactured by electrospinning and then coated with cross-linked poly (3,4-ethylenedioxythiophene) doped with poly (styrene sulfonic acid) (PEDOT:PSS) by spin coating or dip coating. These scaffolds have been characterized by scanning electron microscopy (SEM) imaging and attenuated total reflectance Fourier-transform infrared (ATR-FTIR) spectroscopy. The electrical conductivity was measured by the four-probe method at values of 28.3 S·m−1 for spin coated fibers and 147 S·m−1 for dip coated samples, which correspond, respectively, to an increase of about 105 and 106 times in relation to the electrical conductivity of PBI fibers. Human bone marrow-derived mesenchymal stromal cells (hBM-MSCs) cultured on the produced scaffolds for one week showed high viability, typical morphology and proliferative capacity, as demonstrated by calcein fluorescence staining, 40 ,6-diamidino-2-phenylindole (DAPI)/Phalloidin staining and MTT [3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide] assay. Therefore, all fiber samples demonstrated biocompatibility. Overall, our findings highlight the great potential of PEDOT:PSS-coated PBI electrospun scaffolds for a wide variety of biomedical applications, including their use as reliable in vitro models to study pathologies and the development of strategies for the regeneration of electroactive tissues or in the design of new electrodes for in vivo electrical stimulation protocols.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSordini, L.; Silva, J.C.; Garrudo, F.F.F.; Rodrigues, C.A.V.; Marques, A.C.; Linhardt, R.J.; Cabral, J.M.S.; Morgado, J.; Ferreira, F.C. PEDOT:PSS-Coated Polybenzimidazole Electroconductive Nanofibers for Biomedical Applications. Polymers 2021, 13, 2786. https://doi.org/10.3390/polym13162786pt_PT
dc.identifier.doi10.3390/polym13162786pt_PT
dc.identifier.issn2073-4360
dc.identifier.urihttp://hdl.handle.net/10400.8/8304
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMesenchymal stem cellspt_PT
dc.subjectPEDOT:PSSpt_PT
dc.subjectPBIpt_PT
dc.subjectElectrospinningpt_PT
dc.subjectNanofiberspt_PT
dc.subjectElectroconductivept_PT
dc.titlePEDOT:PSS-coated polybenzimidazole electroconductive nanofibers for biomedical applicationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titlePolymerspt_PT
oaire.citation.volume13pt_PT
person.familyNameSilva
person.givenNameJoão Carlos
person.identifier1715750
person.identifier.ciencia-id7F1B-FF18-FBAA
person.identifier.orcid0000-0003-4773-6771
person.identifier.scopus-author-id57214120948
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationfc1664a0-a117-496f-9f4f-5369e45c9df8
relation.isAuthorOfPublication.latestForDiscoveryfc1664a0-a117-496f-9f4f-5369e45c9df8

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