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Fabrication and characterisation of PCL and PCL/PLA scaffolds for tissue engineering

2014-03-11Artigo científico Acesso restrito
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datacite.subject.fosEngenharia e Tecnologia::Engenharia Mecânica
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorPatrício, T.
dc.contributor.authorDomingos, M.
dc.contributor.authorGloria, A.
dc.contributor.authorD'Amora, U.
dc.contributor.authorCoelho, J. F.
dc.contributor.authorBartolo, P.J.
dc.date.accessioned2026-07-15T10:12:49Z
dc.date.available2026-07-15T10:12:49Z
dc.date.issued2014-03-11
dc.description.abstractPurpose – The main purpose of this research work is to study the effect of poly lactic acid (PLA) addition into poly (e-caprolactone) (PCL) matrices, as well the influence of the mixing process on the morphological, thermal, chemical, mechanical and biological performance of the 3D constructs produced with a novel biomanufacturing device (BioCell Printing). Design/methodology/approach – Two mixing processes are used to prepare PCL/PLA blends, namely melt blending and solvent casting. PCL and PCL/PLA scaffolds are produced via BioCell Printing using a 300-mm nozzle, 0/908 lay down pattern and 350-mm pore size. Several techniques such as scanning electron microscopy (SEM), simultaneous thermal analyzer (STA), nuclear magnetic resonance (NMR), static compression analysis and Alamar BlueTM are used to evaluate scaffold’s morphological, thermal, chemical, mechanical and biological properties. Findings – Results show that the addition of PLA to PCL scaffolds strongly improves the biomechanical performance of the constructs. Additionally, polymer blends obtained by solvent casting present better mechanical and biological properties, compared to blends prepared by melt blending. Originality/value – This paper undertakes a detailed study on the effect of the mixing process on the biomechanical properties of PCL/PLA scaffolds. Results will enable to prepare customized PCL/PLA scaffolds for tissue engineering applications with improved biological and mechanical properties, compared to PCL scaffolds alone. Additionally, the accuracy and reproducibility of by the BioCell Printing enables to modulate the micro/macro architecture of the scaffolds enhancing tissue regeneration.eng
dc.identifier.citationPatrício T, Domingos M, Gloria A, D'Amora U, Coelho J, Bártolo P (2014), "Fabrication and characterisation of PCL and PCL/PLA scaffolds for tissue engineering". Rapid Prototyping Journal, Vol. 20 No. 2 pp. 145–156, doi: https://doi.org/10.1108/RPJ-04-2012-0037
dc.identifier.doi10.1108/rpj-04-2012-0037
dc.identifier.issn1355-2546
dc.identifier.urihttp://hdl.handle.net/10400.8/16593
dc.language.isoeng
dc.peerreviewedyes
dc.publisherEmerald
dc.relation.hasversionhttps://v2.sherpa.ac.uk/id/publication/2982
dc.relation.ispartofRapid Prototyping Journal
dc.rights.uriN/A
dc.subjectPolymers
dc.subjectScaffolds
dc.subjectFused deposition modelling
dc.subjectBiological analysis and testing
dc.titleFabrication and characterisation of PCL and PCL/PLA scaffolds for tissue engineeringeng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage156
oaire.citation.issue2
oaire.citation.startPage145
oaire.citation.titleRapid Prototyping Journal
oaire.citation.volume20
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameFernandes Patrício
person.familyNameDomingos
person.familyNameBartolo
person.givenNameTatiana Marisa
person.givenNameMarco
person.givenNamePaulo
person.identifierL-2781-2015
person.identifier203086
person.identifier.ciencia-idEF1C-430E-9F29
person.identifier.ciencia-idB512-2D06-5897
person.identifier.ciencia-id5810-9BF9-4522
person.identifier.orcid0000-0003-0672-9014
person.identifier.orcid0000-0002-6693-790X
person.identifier.orcid0000-0003-3683-726X
person.identifier.ridF-2421-2013
person.identifier.scopus-author-id55749853300
person.identifier.scopus-author-id6603353041
relation.isAuthorOfPublicationc256ec7c-9a07-42d9-84a2-6885b5392a00
relation.isAuthorOfPublication1fb3bd4b-f499-4db6-93c1-3a671f116d07
relation.isAuthorOfPublicationab44d1ae-46d0-45c2-b19f-200024b5a990
relation.isAuthorOfPublication.latestForDiscoveryc256ec7c-9a07-42d9-84a2-6885b5392a00

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