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Correlation between the potency of flavonoids for cytochrome c reduction and inhibition of cardiolipin-induced peroxidase activity

2017-03-20Journal article Restricted access
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dc.contributor.authorLagoa, Ricardo
dc.contributor.authorAlejandro K. Samhan‐Arias
dc.contributor.authorCarlos Gutierrez‐Merino
dc.date.accessioned2025-09-05T13:59:41Z
dc.date.available2025-09-05T13:59:41Z
dc.date.issued2017-03-20
dc.description.abstractThere are large differences between flavonoids to protect against apoptosis, a process in which cytochrome c (Cyt c) plays a key role. In this work, we show that 7 of 13 flavonoids studied have a capacity to reduce Cyt c similar or higher than ascorbate, the flavonols quercetin, kaempferol and myricetin, flavanol epigallocatechin-gallate, anthocyanidins cyanidin and malvidin, and the flavone luteolin. In contrast, the kaempferol 3(O)- and 3,40(O)-methylated forms, the flavanone naringenin, and also apigenin and chrysin, had a negligible reducing capacity. Equilibrium dialysis and quenching of 1,6-diphenyl-1,3,5-hexatriene fluorescence experiments showed that flavonoids did not interfere with Cyt c binding to cardiolipin (CL)/phosphatidylcholine (PC) vesicles. However, the CL-induced loss of Cyt c Soret band intensity was largely attenuated by flavonoids, pointing out a stabilizing action against Cyt c unfolding in the complex. Moreover, flavonoids that behave as Cyt c reductants also inhibited the pro-apoptotic CL-induced peroxidase activity of Cyt c, indicating that modulation of Cyt c signaling are probable mechanisms behind the protective biological activities of flavonoids.eng
dc.description.sponsorshipThis work has been financed with research project BFU2011-30178 of the Spanish Ministerio de Econom ıa y Competitividad and grant GR15139 to the research group BBB008 of the Plan Regional de I1D1I of the Junta de Extremadura (Spain). These research grants have been co-financed with the European Fund for Economic and Regional Development (FEDER). Alejandro K. Samhan-Arias is supported by Post-doctoral Fellowship SFRH/BPD/100069/2014 of the Fundação para a Ciência e Tecnologia, Portugal.
dc.identifier.citationLagoa R, Samhan-Arias AK, Gutierrez-Merino C. Correlation between the potency of flavonoids for cytochrome c reduction and inhibition of cardiolipin-induced peroxidase activity. Biofactors. 2017 May 6;43(3):451-468. doi: 10.1002/biof.1357. Epub 2017 Mar 20. PMID: 28317253
dc.identifier.doi10.1002/biof.1357
dc.identifier.issn0951-6433
dc.identifier.issn1872-8081
dc.identifier.urihttp://hdl.handle.net/10400.8/13998
dc.language.isoeng
dc.peerreviewedyes
dc.publisherWiley
dc.relationBFU2011-30178
dc.relationSFRH/BPD/100069/2014
dc.relation.hasversionhttps://pubmed.ncbi.nlm.nih.gov/28317253/
dc.relation.ispartofBioFactors
dc.rights.uriN/A
dc.subjectMetalloproteins
dc.subjectAntioxidants
dc.subjectFlavonoids
dc.subjectMitochondria
dc.subjectOxidative stress
dc.titleCorrelation between the potency of flavonoids for cytochrome c reduction and inhibition of cardiolipin-induced peroxidase activityeng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage468
oaire.citation.issue3
oaire.citation.startPage451
oaire.citation.titleBiofactors
oaire.citation.volume43
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameLagoa
person.givenNameRicardo
person.identifier124357
person.identifier.ciencia-id5C18-A29A-44AB
person.identifier.orcid0000-0003-2375-6612
person.identifier.scopus-author-id23051352300
relation.isAuthorOfPublication8a139213-9a89-4bd3-93ee-1e332519f96b
relation.isAuthorOfPublication.latestForDiscovery8a139213-9a89-4bd3-93ee-1e332519f96b

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