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The marine origin of drugs

2015-03-23Book part Open access
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datacite.subject.fosCiências Naturais::Ciências da Terra e do Ambiente
datacite.subject.sdg12:Produção e Consumo Sustentáveis
datacite.subject.sdg14:Proteger a Vida Marinha
datacite.subject.sdg15:Proteger a Vida Terrestre
dc.contributor.authorHorta, André
dc.contributor.authorAlves, Celso
dc.contributor.authorPinteus, Susete
dc.contributor.authorPedrosa, Rui
dc.date.accessioned2025-07-08T18:05:04Z
dc.date.available2025-07-08T18:05:04Z
dc.date.issued2015-03-23
dc.descriptionChapter 13: The marine origin of drugs (Pages: 293-316):
dc.description.abstractOutstanding research work has been done in the last 50 years, resulting in the increase of knowledge related to marine organisms as producers of high value-added biomolecules. This chapter highlights some of the main topics related with marine drug origin, with a particular emphasis on the unique marine chemical ecology environmental as critical conditions for marine drug production. Additionally, some of the most relevant marine drug success stories associated to their therapeutic use, or as research pharmacology tools, is also described, including marine toxin drugs (e.g. tetradotoxin, okadaic acid, Cytarabine, Eribulin mesylate and Ziconotide). The marine drug origin of the FDA-approved drugs, as well all the marine compounds under clinical trials evaluations (phases III, II and I), are the main targets of this chapter.eng
dc.identifier.citationHorta, A., Alves, C., Pinteus, S. and Pedrosa, R. (2015). The marine origin of drugs. In Phycotoxins (eds L.M. Botana and A. Alfonso). https://doi.org/10.1002/9781118500354.ch13
dc.identifier.doi10.1002/9781118500354.ch13
dc.identifier.isbn9781118500361
dc.identifier.isbn9781118500354
dc.identifier.urihttp://hdl.handle.net/10400.8/13579
dc.language.isoeng
dc.peerreviewedyes
dc.publisherWiley
dc.relation.hasversionhttps://onlinelibrary.wiley.com/doi/abs/10.1002/9781118500354.ch13
dc.relation.ispartofPhycotoxins
dc.rights.uriN/A
dc.subjectChemical ecology
dc.subjectCytarabine
dc.subjectEribulin
dc.subjectMarine bacteria
dc.subjectOkadaic acid
dc.subjectTetrodotoxin
dc.subjectZiconotide
dc.titleThe marine origin of drugseng
dc.typebook part
dspace.entity.typePublication
oaire.citation.endPage316
oaire.citation.startPage293
oaire.citation.titlePhycotoxins: Chemistry and Biochemistry
oaire.versionhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43
person.familyNameHorta
person.familyNameAlves
person.familyNamePinteus
person.familyNamePedrosa
person.givenNameAndré
person.givenNameCelso
person.givenNameSusete
person.givenNameRui
person.identifier159091
person.identifier159292
person.identifier349272
person.identifier.ciencia-id501C-F268-2E60
person.identifier.ciencia-id661E-9677-74C5
person.identifier.ciencia-id3817-33DE-919E
person.identifier.orcid0000-0003-2178-1849
person.identifier.orcid0000-0003-1581-2127
person.identifier.orcid0000-0002-3290-3111
person.identifier.orcid0000-0003-0970-0575
person.identifier.ridB-2980-2015
person.identifier.ridB-4815-2015
person.identifier.scopus-author-id55655320600
person.identifier.scopus-author-id55654969100
person.identifier.scopus-author-id55655328300
person.identifier.scopus-author-id7005010300
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BooK: Phycotoxins are a diverse group of poisonous substances produced by certain seaweed and algae in marine and fresh waters and are important to the scientific community for many reasons, the most obvious being that they pose food safety issues which requires a large investment to regularly monitor the presence of these compounds in foods. Phycotoxins: Chemistry and Biochemistry, second edition presents the most updated information available on phycotoxins. Major emphases are given to chemistry and biochemistry, while origins, mechanism of action, toxicology, and analytical methodology are also covered. Since the publication of the first edition, there have been major advances in the science of marine and aquatic toxins, as well as advances in toxicology, analytical chemistry and pharmacology. This fully revised and updated edition includes several new chapters, including those on ciguatoxins, pinnatoxin, ichthyotoxins, as well as new chapters on food safety control of marine toxins, climate change and water toxins, and microalgae as a source of nutraceuticals. The book will be of interest to toxicologists, marine, food, and plant scientists, as well as researchers and academics in the areas of food science, medicine, public health, toxicology, pharmacology and marine biology.
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