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Collagen surface modified poly(ε-caprolactone) scaffolds with improved hydrophilicity and cell adhesion properties

2014-11-01Artigo científico Acesso restrito
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datacite.subject.fosEngenharia e Tecnologia::Engenharia Mecânica
datacite.subject.fosCiências Naturais::Ciências Físicas
datacite.subject.fosCiências Naturais::Outras Ciências Naturais
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorSousa, Inês
dc.contributor.authorMendes, Ausenda
dc.contributor.authorPereira, Rúben F.
dc.contributor.authorBártolo, Paulo J.
dc.date.accessioned2026-07-06T14:53:12Z
dc.date.available2026-07-06T14:53:12Z
dc.date.issued2014-11-01
dc.description.abstractPoly(ε-caprolactone) (PCL)/collagen scaffolds were produced using a four-step procedure comprising (i) the fabrication of PCL scaffolds through an additive bioextrusion system, (ii) the PCL surface modification using a plasma treatment, (iii) the acrylic acid (AAc) grafting by ultraviolet (UV) polymerization, and (iv) the immobilization of collagen into the scaffold surface through the carbodiimide chemistry. This procedure allowed the quick fabrication of highly porous scaffolds with interconnected pores, well-defined internal architecture and improved cell adhesion properties. The immobilization of collagen into the PCL surface led to a significant enhancement in the hydrophilicity, while the biological tests showed a further improvement in the adhesion of fibroblast cells. These results indicate that the collagen surface modification is an effective strategy to render the hydrophobic nature of PCL and overcome the limited cell interaction of 3D PCL scaffolds.eng
dc.description.sponsorshipThe authors are grateful to the Portuguese Foundation for Science and Technology for supporting this work through the strategic project Pest-OE/EME/UI4044/2011. Rúben Pereira is grateful for the financial support from Portuguese Foundation for Science and Technology through the Grant SFRH/BD/91151/2012.
dc.identifier.citationInês Sousa, Ausenda Mendes, Rúben F. Pereira, Paulo J. Bártolo, Collagen surface modified poly(ε-caprolactone) scaffolds with improved hydrophilicity and cell adhesion properties, Materials Letters, Volume 134, 2014, Pages 263-267, ISSN 0167-577X, https://doi.org/10.1016/j.matlet.2014.06.132.
dc.identifier.doi10.1016/j.matlet.2014.06.132
dc.identifier.eissn1873-4979
dc.identifier.issn0167-577X
dc.identifier.urihttp://hdl.handle.net/10400.8/16546
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationStrategic Project - UI 4044 - 2011-2012
dc.relationDISPOSITIVO DE BIOFABRICAÇÃO IN SITU PARA ENGENHARIA DE TECIDOS DA PELE
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S0167577X14011811?via%3Dihub
dc.relation.ispartofMaterials Letters
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBioExtruder
dc.subjectCollagen
dc.subjectPoly(ε-caprolactone)
dc.subjectScaffold
dc.subjectSurface modification
dc.titleCollagen surface modified poly(ε-caprolactone) scaffolds with improved hydrophilicity and cell adhesion propertieseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberPEst-OE/EME/UI4044/2011
oaire.awardNumberSFRH/BD/91151/2012
oaire.awardTitleStrategic Project - UI 4044 - 2011-2012
oaire.awardTitleDISPOSITIVO DE BIOFABRICAÇÃO IN SITU PARA ENGENHARIA DE TECIDOS DA PELE
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FEME%2FUI4044%2F2011/PT
oaire.awardURIhttp://hdl.handle.net/10400.8/12921
oaire.citation.endPage267
oaire.citation.startPage263
oaire.citation.titleMaterials Letters
oaire.citation.volume134
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamFARH
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.affiliation.nameCDRSP
person.familyNameSousa
person.familyNameMendes
person.familyNameBrás Pereira
person.familyNameBartolo
person.givenNameInês
person.givenNameAusenda
person.givenNameRúben Filipe
person.givenNamePaulo
person.identifier1337969
person.identifier203086
person.identifier.ciencia-id9417-153E-4473
person.identifier.ciencia-id5810-9BF9-4522
person.identifier.orcid0000-0001-7987-1033
person.identifier.orcid0000-0003-3004-8972
person.identifier.orcid0000-0002-7255-3400
person.identifier.orcid0000-0003-3683-726X
person.identifier.ridP-8503-2018
person.identifier.ridF-2421-2013
person.identifier.scopus-author-id7102443940
person.identifier.scopus-author-id55421048100
person.identifier.scopus-author-id6603353041
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
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Poly(ε-caprolactone) (PCL)/collagen scaffolds were produced using a four-step procedure comprising (i) the fabrication of PCL scaffolds through an additive bioextrusion system, (ii) the PCL surface modification using a plasma treatment, (iii) the acrylic acid (AAc) grafting by ultraviolet (UV) polymerization, and (iv) the immobilization of collagen into the scaffold surface through the carbodiimide chemistry. This procedure allowed the quick fabrication of highly porous scaffolds with interconnected pores, well-defined internal architecture and improved cell adhesion properties. The immobilization of collagen into the PCL surface led to a significant enhancement in the hydrophilicity, while the biological tests showed a further improvement in the adhesion of fibroblast cells. These results indicate that the collagen surface modification is an effective strategy to render the hydrophobic nature of PCL and overcome the limited cell interaction of 3D PCL scaffolds.
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