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Characterization of Biocompatible Poly(Ethylene Glycol)-Dimethacrylate Hydrogels for Tissue Engineering

2019-04-09Journal article Open access
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dc.contributor.authorLopes, João
dc.contributor.authorFonseca, Rita
dc.contributor.authorViana, Tânia
dc.contributor.authorFernandes, Cristiana
dc.contributor.authorMorouço, Pedro
dc.contributor.authorMoura, Carla
dc.contributor.authorBiscaia, Sara
dc.date.accessioned2023-04-05T14:07:23Z
dc.date.available2023-04-05T14:07:23Z
dc.date.issued2019-04-09
dc.descriptionAcknowledgements: This work is supported by the Fundação para a Ciência e a Tecnologia (FCT) and Centro2020 through the Project references: UID/Multi/04044/2013 and PAMI - ROTEIRO/0328/2013 (Nº022158). It is also funded by the projects insitu.Biomas (POCI-01-0247-FEDER-017771), and NEXT. parts (POCI-01-0247-FEDER-017963) from the Portuguese National Innovation Agency.pt_PT
dc.description.abstractTissue Engineering depends on broadly techniques to regenerate tissues and/or organ functions. To do so, tailored polymeric and/or hydrogel scaffolds may be used to ensure the appropriate regeneration. Hydrogels are suitable materials for constructing cell-laden matrices as they can be produced with incorporation of cells and rapidly cross-linked in situ through photopolymerisation reactions. Measurement of the polymerization degree, as well as resistance to compression and water retention are fundamental tests to evaluate the characteristics of hydrogels. In this work, free-radical polymerisation of poly(ethylene glycol)-dimethacrylate (PEGDMA) in UV light was assessed. Several hydrogels with different photoinitiator and water contents were produced to evaluate their influence on hydrogels behaviour. Experiments showed that variations on water and photoinitiator content induce changes in the physical and chemical behaviour of hydrogels. As it was found, water content prevents polymerisation to occur and reduces the mechanical properties of hydrogels weakening them. Furthermore, differences were found in varying water content from 15 to 30%, since this increase turned hydrogels more fragile and increase their stabilization time for water retention.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLopes, J., Fonseca, R., Viana, T., Fernandes, C., Morouço, P., Moura, C., & Biscaia, S. (2019). Characterization of Biocompatible Poly(Ethylene Glycol)-Dimethacrylate Hydrogels for Tissue Engineering. Applied Mechanics and Materials, 890, 290–300. https://doi.org/10.4028/www.scientific.net/amm.890.290pt_PT
dc.identifier.doihttps://doi.org/10.4028/www.scientific.net/AMM.890.290pt_PT
dc.identifier.eissn1662-7482
dc.identifier.urihttp://hdl.handle.net/10400.8/8334
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTrans Tech Publicationspt_PT
dc.relationCentre for Rapid and Sustainable Product Development
dc.relation.publisherversionhttps://www.scientific.net/AMM.890.290pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectHydrogelpt_PT
dc.subjectPhotoinitiatorpt_PT
dc.subjectPoly(ethylene glycol)-dimethacrylatept_PT
dc.subjectMechanical propertiespt_PT
dc.subjectFTIRpt_PT
dc.titleCharacterization of Biocompatible Poly(Ethylene Glycol)-Dimethacrylate Hydrogels for Tissue Engineeringpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for Rapid and Sustainable Product Development
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04044%2F2013/PT
oaire.citation.endPage300pt_PT
oaire.citation.startPage290pt_PT
oaire.citation.titleApplied Mechanics and Materialspt_PT
oaire.citation.volume890pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameFonseca
person.familyNameFernandes
person.familyNameMorouço
person.familyNameMonteiro de Moura
person.familyNameBiscaia
person.givenNameAna Rita
person.givenNameCristiana Henriques
person.givenNamePedro
person.givenNameCarla Sofia
person.givenNameSara
person.identifier435983
person.identifier.ciencia-id6E17-49F2-D317
person.identifier.ciencia-id0C18-D3D1-D625
person.identifier.ciencia-idF619-3996-742A
person.identifier.ciencia-id671C-8FEC-A14A
person.identifier.ciencia-id0516-3C03-93F3
person.identifier.orcid0000-0002-5088-8509
person.identifier.orcid0000-0001-6371-800X
person.identifier.orcid0000-0002-5956-9790
person.identifier.orcid0000-0003-2610-1005
person.identifier.orcid0000-0002-2609-6878
person.identifier.ridK-9545-2013
person.identifier.ridO-1146-2013
person.identifier.scopus-author-id24339135400
person.identifier.scopus-author-id55867382400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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