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Mesenchymal Stem Cells and Biomaterials Systems – Perspectives for Skeletal Muscle Tissue Repair and Regeneration

2015Journal article Open access
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datacite.subject.fosEngenharia e Tecnologia
datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorCaseiro, A.R.
dc.contributor.authorPereira, T.
dc.contributor.authorBártolo, P. J.
dc.contributor.authorSantos, J.D.
dc.contributor.authorLuís, A.L.
dc.contributor.authorMaurício, A.C.
dc.date.accessioned2025-10-28T12:18:09Z
dc.date.available2025-10-28T12:18:09Z
dc.date.issued2015
dc.descriptionConference name 4th International Conference on Tissue Engineering - An ECCOMAS Thematic Conference, ICTE 2015
dc.descriptionConference date 25 June 2015 - 27 June 2015
dc.descriptionConference city Lisboa, Portugal
dc.description.abstractSkeletal muscle is essential in voluntary movement and other major vital functions. Muscle injuries are important in clinical practice and, despite skeletal muscle's good regenerative ability, severe tissue loss impairs complete myofibre regeneration, limiting structural and functional recovery of the affected muscle, eventually leading to the development of non-contractile fibrous scar. The intrinsic healing mechanisms rely in great extent on the residing progenitor population but significant drawbacks to their practical application in regenerative strategies boosted the search for alternative cell sources, such as extra-fetal mesenchymal stem cells (MSCs). MSCs have demonstrated to positively influence the regeneration of different disease models. When severe volumetric muscle tissue loss occurs, the body is seldom capable of replacing the lost portions with fully functional tissue. A rational strategy to aid the healing of such situations is the application of biomaterial implants that provide a structural matrix for the ingrowth of regenerating muscle fibres. Both synthetic and natural biomaterials have been hypothesized for this purpose and some have reached as far clinical cases applications. Obvious improvements are observed in most cases, but reaction to some biomaterials and functional recovery are still a challenge. The addition of MSCs to the biomaterials seems to improve the systems' performance in the overall regenerative milieu. This strategies promote scaffold's vascularization and integration, as well as accelerated tissue ingrowth and reduces scar formation, resulting in improved recovery rates at both structural and functional levels.eng
dc.description.sponsorshipThis research was supported by System of Incentives for Research and Technological development of QREN in the scope of project nº 38853/2013 - DEXGELERATION : “Soluções avançadas de regeneração óssea com base em hidrogéis de dextrino - by the European Community FEDER fund through ON2 - O Novo Norte – North Portugal Regional Operational Program 2007-2013, by Project nº 34128 – BEPIM II: “Microdispositivos biomédicos com capacidade osteointegrativa por ȝPIM – BEPIM II, funded by AdI, and by the program COMPETE – Programa Operacional Factores de Competitividade, Project Pest-OE/AGR/UI0211/2011, by FCT project PTDC/CVT/103081/2008, and CDRsp’s Strategic Project – UI-4044-2011-2012 (Pest-OE/EME/UI4044/2011) funding from FCT. AR Caseiro would also like to acknowledge the FCT for the PhD grant SFRH/BD/101174/2014.
dc.identifier.citationA.R. Caseiro, T. Pereira, P.J. Bártolo, J.D. Santos, A.L. Luís, A.C. Maurício, Mesenchymal Stem Cells and Biomaterials Systems – Perspectives for Skeletal Muscle Tissue Repair and Regeneration, Procedia Engineering, Volume 110,2015, Pages 90-97, ISSN 1877-7058, https://doi.org/10.1016/j.proeng.2015.07.014.
dc.identifier.doi10.1016/j.proeng.2015.07.014
dc.identifier.issn1877-7058
dc.identifier.urihttp://hdl.handle.net/10400.8/14409
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationStrategic Project - UI 211 - 2011-2012
dc.relationStrategic Project - UI 4044 - 2011-2012
dc.relationSkeletal muscle regeneration through the application of cellular therapies and biomaterials - Translation to the veterinary practicealterado para:Cell-based Therapies in Regenerative Medicine – Thetherapeuthic potential of Umbilical Cord and Dental Pulp derived Stem/ Stromal Cells
dc.relationNew approaches for inactivation, treatment and immunoprophylaxy of cryptosporidiosis
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S1877705815012552
dc.relation.ispartofProcedia Engineering
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectBiomaterials
dc.subjectDental pulp
dc.subjectMesenchymal stem cells
dc.subjectSecretome
dc.subjectSkeletal muscle
dc.subjectUmbilical cord
dc.subjectWharton's jelly
dc.titleMesenchymal Stem Cells and Biomaterials Systems – Perspectives for Skeletal Muscle Tissue Repair and Regenerationeng
dc.title.alternative4th International Conference on Tissue Engineering, ICTE2015eng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 211 - 2011-2012
oaire.awardTitleStrategic Project - UI 4044 - 2011-2012
oaire.awardTitleSkeletal muscle regeneration through the application of cellular therapies and biomaterials - Translation to the veterinary practicealterado para:Cell-based Therapies in Regenerative Medicine – Thetherapeuthic potential of Umbilical Cord and Dental Pulp derived Stem/ Stromal Cells
oaire.awardTitleNew approaches for inactivation, treatment and immunoprophylaxy of cryptosporidiosis
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0211%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FEME%2FUI4044%2F2011/PT
oaire.awardURIhttp://hdl.handle.net/10400.8/14319
oaire.awardURIhttp://hdl.handle.net/10400.8/14408
oaire.citation.endPage97
oaire.citation.startPage90
oaire.citation.titleProcedia Engineering
oaire.citation.volume110
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamConcurso para Projectos de I&D em todos os Domínios Científicos - 2008
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameCaseiro Santos
person.familyNameBartolo
person.givenNameAna Rita
person.givenNamePaulo
person.identifier203086
person.identifier.ciencia-id5810-9BF9-4522
person.identifier.orcid0000-0002-1143-2461
person.identifier.orcid0000-0003-3683-726X
person.identifier.ridF-2421-2013
person.identifier.scopus-author-id6603353041
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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