Repository logo
 
Publication

Strategy to improve the mechanical properties of bioabsorbable materials based on chitosan for orthopedic fixation applications

2020-03Journal article Restricted access
Simple item page
dc.contributor.authorFigueiredo, Lígia
dc.contributor.authorFonseca, Rita
dc.contributor.authorPinto, Luís F. V.
dc.contributor.authorFerreira, Frederico Castelo
dc.contributor.authorAlmeida, Amélia
dc.contributor.authorRodrigues, Alexandra
dc.date.accessioned2023-04-19T14:56:31Z
dc.date.available2023-04-19T14:56:31Z
dc.date.issued2020-03
dc.descriptionThe authors thank Bioceramed S.A. for providing the materials used in the present study and Fundação para a Ciência e Tecnologia (FCT) for the PhD grant SFRH/BD/51949/2012. Funding received from FCT (UID/BIO/04565/2019), from Programa Operacional Regional de Lisboa 2020 (Project N. 007317) and PAC (Project 016394) is also acknowledged.pt_PT
dc.description.abstractBioabsorbable polymeric fixation devices have been used as an alternative to metallic implants in orthopedics,preventing the stress shielding effect and avoiding a second surgery for implant removal. However,several problems are still associated with current bioabsorbable implants, including the limited mechanical stiffness and strength, and the adverse tissue reactions generated. To minimize or even eliminate the problems associated with these implants, strategies have been developed to synthesize new implant materials based on chitosan. To overcome the brittle behavior of most 3D chitosan-based structures, glycerol and sorbitol were blended to chitosan and the effect of these plasticizers in the produced specimens was analyzed by flexural tests, Berkovich tests, scanning electron microscopy (SEM) and micro-CT analyzes. The improvement of the mechanical properties was also tested by adding ceramics, namely hydroxyapatite powder and biphasic mixtures of hydroxyapatite (HA) and beta-tricalcium phosphate (β-TCP). In the plasticizers group, the best combination of the measured properties was obtained for chitosan with 10% glycerol (flexural strength of 53.8 MPa and indentation hardness of 19.4 kgf/mm2), while in the ceramics group the best mechanical behavior was obtained for chitosan with 10% HAþβ-TCP powder (flexural strength of 67.5 MPa and indentation hardness 28.2 kgf/mm2). All the tested material compositions were dense and homogeneous, fundamental condition for a good implant performance. These are encouraging results, which support the continued development of chitosan-based materials for orthopedic fixation applications.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFigueiredo, L., Fonseca, R., Pinto, L. F. V., Ferreira, F. C., Almeida, A., & Rodrigues, A. (2020). Strategy to improve the mechanical properties of bioabsorbable materials based on chitosan for orthopedic fixation applications. Journal of the Mechanical Behavior of Biomedical Materials, 103. https://doi.org/10.1016/j.jmbbm.2019.103572pt_PT
dc.identifier.doi10.1016/j.jmbbm.2019.103572pt_PT
dc.identifier.issn1751-6161
dc.identifier.urihttp://hdl.handle.net/10400.8/8421
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationPROCESS IMPROVEMENT AND BIOLOGIC BEHAVIOR OF CHITOSAN BASED ABSORBABLE IMPLANTS
dc.relationInstitute for Bioengineering and Biosciences
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectBioabsorbable polymerspt_PT
dc.subjectChitosanpt_PT
dc.subjectPlasticizerspt_PT
dc.subjectCeramicspt_PT
dc.subjectMechanical propertiespt_PT
dc.subjectMicrostructurept_PT
dc.titleStrategy to improve the mechanical properties of bioabsorbable materials based on chitosan for orthopedic fixation applicationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePROCESS IMPROVEMENT AND BIOLOGIC BEHAVIOR OF CHITOSAN BASED ABSORBABLE IMPLANTS
oaire.awardTitleInstitute for Bioengineering and Biosciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F51949%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FBIO%2F04565%2F2019/PT
oaire.citation.titleJournal of the Mechanical Behavior of Biomedical Materialspt_PT
oaire.citation.volume103pt_PT
oaire.fundingStreamOE
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication969d652b-646e-4875-917e-8159a6a75a59
relation.isProjectOfPublication84f0e711-a0c5-49df-9af7-f7b2498375f7
relation.isProjectOfPublication.latestForDiscovery84f0e711-a0c5-49df-9af7-f7b2498375f7

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Figueiredo et al_2020_Strategy to improve the mechanical properties of bioabsorbable materials based on chitosan for orthopedic fixation applications.pdf
Size:
2.62 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.32 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CDRsp - Artigos em revistas internacionais