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Composite Central Face Design—An Approach to Achieve Efficient Alginate Microcarriers

2019-11Journal article Open access
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dc.contributor.authorValente, J.F.A.
dc.contributor.authorDias, J.R.
dc.contributor.authorSousa, A.
dc.contributor.authorAlves, N.
dc.date.accessioned2023-06-13T09:44:15Z
dc.date.available2023-06-13T09:44:15Z
dc.date.issued2019-11
dc.descriptionFunding: This work was supported by Portuguese Agency for Innovation (PT2020) through the projects (CENTRO-01-0145-FEDER-000014) and (POCI-01-0247-FEDER-017771). It was also supported by the project PAMI – Portuguese Additive Manufacturing Initiative (project nº22158 – SAICT- AAC nº 01/SAICT/2016) and also, by the CDRSP– ID/Multi/04044/2019, funded by the Portuguese Government through FCT/MCTES and co-funded by the European Regional Development Fund through the Partnership Agreement PT2020. This work was also supported by funds from the Health Sciences Research Center (CICS-UBI) through National Funds by FCT - Foundation for Science and Technology (UID / Multi / 00709/2019).pt_PT
dc.description.abstractMicroparticulated drug delivery systems have been used as promising encapsulation systems for protecting drugs for in vitro and in vivo applications, enhancing its stability, providing an increased surface to volume ratio, reducing adverse effects, and hence an improvement in bioavailability. Among the studied microparticles, there is a rising interest in the research of alginate microparticles for pharmaceutical and biomedical fields confirming its potential to be used as an effective matrix for drug and cell delivery. Moreover, calcium alginate has been one of the most extensively forming microparticles in the presence of divalent cations providing prolonged drug release and suitable mucoadhesive properties. Regarding the above mentioned, in this research work, we intended to produce Ca-alginate micro-vehicles through electrospraying, presenting high encapsulation efficiency (EE%), reduced protein release across the time, reduced swelling effect, and high sphericity coefficient. To quickly achieve these characteristics and to perform an optimal combination among the percentage of alginate and CaCl2, design of Experiments was applied. The obtained model presented to be statistically significant (p-value < 0.05), with a coefficient of determination of 0.9207, 0.9197, 0.9499, and 0.9637 for each output (EE%, release, swelling, and sphericity, respectively). Moreover, the optimal point (4% of alginate and 6.6% of CaCl2) was successfully validated.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationValente, J. F. A., Dias, J. R., Sousa, A., & Alves, N. (2019). Composite Central Face Design—An Approach to Achieve Efficient Alginate Microcarriers. Polymers, 11(12), 1949. https://doi.org/10.3390/polym11121949pt_PT
dc.identifier.doihttps://doi.org/10.3390/polym11121949pt_PT
dc.identifier.eissn2073-4360
dc.identifier.other1949
dc.identifier.urihttp://hdl.handle.net/10400.8/8581
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationCentre for Rapid and Sustainable Product Development
dc.relationHealth Sciences Research Centre
dc.relation.publisherversionhttps://www.mdpi.com/2073-4360/11/12/1949pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAlginatept_PT
dc.subjectDesign of Experimentspt_PT
dc.subjectElectrosprayingpt_PT
dc.subjectMicroparticlespt_PT
dc.subjectProtein releasept_PT
dc.titleComposite Central Face Design—An Approach to Achieve Efficient Alginate Microcarrierspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for Rapid and Sustainable Product Development
oaire.awardTitleHealth Sciences Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04044%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F00709%2F2019/PT
oaire.citation.issue12pt_PT
oaire.citation.titlePolymerspt_PT
oaire.citation.volume11pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameValente
person.familyNameDias
person.familyNameAlves
person.givenNameJoana
person.givenNameJuliana
person.givenNameNuno
person.identifier826126
person.identifier633669
person.identifier452149
person.identifier.ciencia-id7515-7468-212D
person.identifier.ciencia-id0612-D971-F00D
person.identifier.ciencia-id311E-1559-8F6C
person.identifier.orcid0000-0002-2408-9762
person.identifier.orcid0000-0002-7079-1069
person.identifier.orcid0000-0002-5016-0868
person.identifier.ridM-1930-2019
person.identifier.ridA-6086-2014
person.identifier.ridN-4073-2013
person.identifier.scopus-author-id56273710100
person.identifier.scopus-author-id55749822200
person.identifier.scopus-author-id7006403383
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication9e70a657-1b71-4366-ab59-b9f988a19d5a
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