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Additive manufactured porous biomaterials targeting orthopedic implants: A suitable combination of mechanical, physical and topological properties

2020-02Journal article Open access
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datacite.subject.fosEngenharia e Tecnologia::Engenharia Química
datacite.subject.fosCiências Naturais::Outras Ciências Naturais
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorBartolomeu, F.
dc.contributor.authorDourado, N.
dc.contributor.authorPereira, F.
dc.contributor.authorAlves, N.
dc.contributor.authorMiranda, G.
dc.contributor.authorSilva, F. S.
dc.date.accessioned2025-09-25T09:08:04Z
dc.date.available2025-09-25T09:08:04Z
dc.date.issued2020-02
dc.description.abstractOrthopedic implants are under incessant advancement to improve their interactions with surrounding bone tissue aiming to ensure successful outcomes for patients. A successful biological interaction between implant and surrounding bone depends on the combination of mechanical, physical and topological properties. Hence, Ti6Al4V cellular structures appear as very promising solutions towards the improvement of conventional orthopedic implants. This work addresses a set of fundamental tools that allow improving the design of Ti6Al4V cellular structures produced by Selective Laser Melting (SLM). Three-point bending tests were carried out to estimate the elastic modulus of the produced structures. Morphological analysis allowed to evaluate the dimensional differences that were noticed between the model CAD and the SLM structures. Finite element models (adjusted CAD) were constructed with the experimentally obtained dimensions to replicate the mechanical response of the SLM structures. Linear correlations were systematically found for the dimensions of the SLM structures as a function of the designed model CAD dimensions. This has also been observed for the measured porosities as a function of the designed CAD models. This data can be used in further FE analyses as design guidelines to help engineers fabricating near-net-shape SLM Ti6Al4V cellular structures. Besides, polished and sandblasted surface treatments performed on the Ti6Al4V cellular structures allowed to obtain suitable properties regarding roughness and wettability when compared to as-produced surfaces. The capillarity tests showed that all the analyzed Ti6Al4V structures are able to transport fluid along its structure. The cell viability tests demonstrate Ti6Al4V cellular structures SLM produced did not release toxic substances to the medium, indicating that these structures can assure a suitable environment for cells to proliferate and attach. This study proposes a design methodology for Ti6Al4V cellular structures, that owe suitable mechanical properties but also provide a proper combination of porosity, roughness, wettability, capillarity and cell viability, all of them relevant for orthopedic applications. A Ti6Al4V cellular structured hip implant prototype gathering the suitable features addressed in this study was successfully SLM-produced.eng
dc.description.sponsorshipThis work was supported by FCT through the grants SFRH/BD/128657/2017 and SFRH/BPD/112111/2015, the projects PTDC/EMSTEC/5422/2014 (ADAPTPROSTHESIS) and POCI-01-0145-FEDER-030353 (SMARTCUT) and also by project NORTE 01–0145_FEDER-000018. Additionally, this work was supported by FCT with the reference project UID/EEA/04436/2019, by FEDER funds through the COMPETE 2020 – Programa Operacional Competitividade e Internacionalização (POCI) with the reference project POCI-01-0145-FEDER-006941.
dc.identifier.citationF. Bartolomeu, N. Dourado, F. Pereira, N. Alves, G. Miranda, F.S. Silva, Additive manufactured porous biomaterials targeting orthopedic implants: A suitable combination of mechanical, physical and topological properties, Materials Science and Engineering: C, Volume 107, 2020, 110342, ISSN 0928-4931, https://doi.org/10.1016/j.msec.2019.110342.
dc.identifier.doi10.1016/j.msec.2019.110342
dc.identifier.eissn1873-0191
dc.identifier.issn0928-4931
dc.identifier.urihttp://hdl.handle.net/10400.8/14113
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationSmart design of Titanium/NiTi cellular structured implants by Multi-Material-Selective-Laser-Melting
dc.relationDevelopment of Multi-Functional Structures by Multi-Material Selective Laser Melting/Sintering
dc.relationMicroelectromechanical Systems Research Unit
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S0928493119300153?via%3Dihub#kwrds0010
dc.relation.ispartofMaterials Science and Engineering: C
dc.rights.uriN/A
dc.subjectSelective laser melting
dc.subjectTi6Al4V
dc.subjectCellular structures
dc.subjectDesign tools
dc.subjectElastic modulus
dc.titleAdditive manufactured porous biomaterials targeting orthopedic implants: A suitable combination of mechanical, physical and topological propertieseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleSmart design of Titanium/NiTi cellular structured implants by Multi-Material-Selective-Laser-Melting
oaire.awardTitleDevelopment of Multi-Functional Structures by Multi-Material Selective Laser Melting/Sintering
oaire.awardTitleMicroelectromechanical Systems Research Unit
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F128657%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F112111%2F2015/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FEEA%2F04436%2F2019/PT
oaire.citation.endPage13
oaire.citation.startPage1
oaire.citation.titleMaterials Science and Engineering C
oaire.citation.volume107
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameAlves
person.givenNameNuno
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person.identifier.scopus-author-id7006403383
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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Orthopedic implants are under incessant advancement to improve their interactions with surrounding bone tissue aiming to ensure successful outcomes for patients. A successful biological interaction between implant and surrounding bone depends on the combination of mechanical, physical and topological properties. Hence, Ti6Al4V cellular structures appear as very promising solutions towards the improvement of conventional orthopedic implants. This work addresses a set of fundamental tools that allow improving the design of Ti6Al4V cellular structures produced by Selective Laser Melting (SLM). Three-point bending tests were carried out to estimate the elastic modulus of the produced structures. Morphological analysis allowed to evaluate the dimensional differences that were noticed between the model CAD and the SLM structures. Finite element models (adjusted CAD) were constructed with the experimentally obtained dimensions to replicate the mechanical response of the SLM structures. Linear correlations were systematically found for the dimensions of the SLM structures as a function of the designed model CAD dimensions. This has also been observed for the measured porosities as a function of the designed CAD models. This data can be used in further FE analyses as design guidelines to help engineers fabricating near-net-shape SLM Ti6Al4V cellular structures. Besides, polished and sandblasted surface treatments performed on the Ti6Al4V cellular structures allowed to obtain suitable properties regarding roughness and wettability when compared to as-produced surfaces. The capillarity tests showed that all the analyzed Ti6Al4V structures are able to transport fluid along its structure. The cell viability tests demonstrate Ti6Al4V cellular structures SLM produced did not release toxic substances to the medium, indicating that these structures can assure a suitable environment for cells to proliferate and attach. This study proposes a design methodology for Ti6Al4V cellular structures, that owe suitable mechanical properties but also provide a proper combination of porosity, roughness, wettability, capillarity and cell viability, all of them relevant for orthopedic applications. A Ti6Al4V cellular structured hip implant prototype gathering the suitable features addressed in this study was successfully SLM-produced.
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