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Bioactivity gradients of cytoprotective and anticancer catechins in skin: Simulation studies for the design of controlled release systems

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dc.contributor.authorSilva, João
dc.contributor.authorVideira, Paula
dc.contributor.authorLagoa, Ricardo
dc.date.accessioned2017-04-12T08:44:49Z
dc.date.available2017-04-12T08:44:49Z
dc.date.issued2017
dc.descriptionConference paper (selected oral communication)pt_PT
dc.description.abstractDermal delivery of catechins may be an effective approach for protection of skin against inflammation, aging and cancer caused by exposure to radiation and environmental toxicants. Catechins are flavonoid-type polyphenols showing capacity to attenuate UV-induced skin injury, carcinogenesis and melanoma metastasis, but the prevalence of beneficial effects depends on compound concentration. In this work, catechin penetration through the skin was simulated to predict the concentration in different layers: stratum corneum, viable epidermis and dermis. By combining these results with expected dose-effect relationships of the compounds, bioactivity profiles were calculated for relevant skin regions. Since the concentration dependences of catechin capacities to protect dermal fibroblasts and to inhibit melanoma cells (data aggregated from published literature) follow different types of dose-effect curves, bioactivity profiles in the skin can be different, even for the same delivery conditions. This method allows to estimate the delivery conditions (time and concentrations) required to achieve the desired biological/pharmacological activities at critical skin strata, namely, viable epidermis and dermis where metastatic melanoma cells and susceptible fibroblasts localize. The work suggests a framework to support the rational design of controlled release systems of topically applied bioactive compounds in therapeutic and investigative delivery.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ. Silva, P. Videira and R. Lagoa, "Bioactivity gradients of cytoprotective and anticancer catechins in skin: Simulation studies for the design of controlled release systems," 2017 IEEE 5th Portuguese Meeting on Bioengineering (ENBENG), Coimbra, Portugal, 2017, pp. 1-4.pt_PT
dc.identifier.doi10.1109/ENBENG.2017.7889467pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.8/2554
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttp://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=7889467&isnumber=7889416pt_PT
dc.subjectResearch Subject Categories::TECHNOLOGY::Bioengineeringpt_PT
dc.subjectBiomedical engineeringpt_PT
dc.subjectBiological system modelingpt_PT
dc.subjectMalignant tumorspt_PT
dc.subjectDiffusion modelpt_PT
dc.subjectResearch Subject Categories::NATURAL SCIENCES::Chemistry::Biochemistrypt_PT
dc.subjectResearch Subject Categories::MEDICINE::Morphology, cell biology, pathology::Morphology::Biomaterialspt_PT
dc.titleBioactivity gradients of cytoprotective and anticancer catechins in skin: Simulation studies for the design of controlled release systemspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceCoimbra (Portugal)pt_PT
oaire.citation.endPage4pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.title5th Portuguese Meeting on Bioengineeringpt_PT
oaire.citation.volume2017 IEEE 5th Portuguese Meeting on Bioengineeringpt_PT
person.familyNameSilva
person.familyNameLagoa
person.givenNameJoão
person.givenNameRicardo
person.identifier124357
person.identifier.ciencia-id9819-5C0E-48C2
person.identifier.ciencia-id5C18-A29A-44AB
person.identifier.orcid0000-0002-6139-6841
person.identifier.orcid0000-0003-2375-6612
person.identifier.scopus-author-id23051352300
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationca7fce54-bbbc-40e8-8816-4b676f3a7c91
relation.isAuthorOfPublication8a139213-9a89-4bd3-93ee-1e332519f96b
relation.isAuthorOfPublication.latestForDiscoveryca7fce54-bbbc-40e8-8816-4b676f3a7c91

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