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Neuro-muscular Regeneration Using Scaffolds with Mesenchymal Stem Cells (MSCs) Isolated from Human Umbilical Cord Wharton's Jelly: Functional and Morphological Analysis Using Rat Sciatic Nerve Neurotmesis Injury Model

2015Journal article Open access
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datacite.subject.fosEngenharia e Tecnologia
datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorCaseiro, Ana Rita
dc.contributor.authorPereira, Tiago
dc.contributor.authorRibeiro, Jorge
dc.contributor.authorAmorim, Irina
dc.contributor.authorFaria, Fátima
dc.contributor.authorBártolo, Paulo Jorge
dc.contributor.authorArmada, Paulo
dc.contributor.authorLuís, Ana Lúcia
dc.contributor.authorMaurício, Ana Colette
dc.date.accessioned2025-12-15T15:31:34Z
dc.date.available2025-12-15T15:31:34Z
dc.date.issued2015
dc.descriptionConference name 4th International Conference on Tissue Engineering - An ECCOMAS Thematic Conference, ICTE 2015, Lisboa
dc.descriptiononference date 25 June 2015 - 27 June 2015
dc.description.abstractPeripheral nerves possess the capacity of self-regeneration after traumatic injury but the extent of regeneration is often poor and may benefit from exogenous factors that enhance growth. Neonatal tissues are routinely discarded at parturition so little ethical controversy attends the harvest of the Mesenchymal Stem Cells (MSCs) which may play an important therapeutic role through the secretion of soluble trophic factors which enhance and assist in repair by paracrine activation of surrounding cells. The use of cellular systems is a rational approach for delivering neurotrophic factors at the nerve lesion site, and in our recent research work we have been evaluating the therapeutic value of MSCs isolated from the Wharton jelly (WJ) in nerve repair associated to different tube-guides made of biodegradable and biocompatible biomaterials. The WJ MSCs in vitro studies included cell characterization by immunocytochemistry, karyotype analysis, tri-lineage differentiation capacity and flow cytometry and also citocompatibility by measuring the intracellular calcium concentration ([Ca2+]i) in the presence of different tube-guides.eng
dc.description.sponsorshipAcknowledgements This research was supported by System of Incentives for Research and Technological development of QREN in the scope of project nº 38853/2013 - DEXGELERATION: “Soluções avançadas de regeneração óssea com base em hidrogéis de dextrino - European Community FEDER fund through Regional Operational Program 2007-2013, by Projects Pest-OE/AGR/UI0211/2011, and Pest-OE/EME/UI4044/2011). AR Caseiro would also like to acknowledge the PhD grant SFRH/BD/101174/2014.
dc.identifier.citationCaseiro, Ana & Pereira, Tiago & Ribeiro, Jorge & Amorim, Irina & Faria, Francisca & Bártolo, Paulo & Armada-da-Silva, Paulo & Luis, Ana & Mauricio, Ana Colette. (2015). Neuro-muscular Regeneration Using Scaffolds with Mesenchymal Stem Cells (MSCs) Isolated from Human Umbilical Cord Wharton's Jelly: Functional and Morphological Analysis Using Rat Sciatic Nerve Neurotmesis Injury Model. Procedia Engineering. 110. 10.1016/j.proeng.2015.07.016.
dc.identifier.doi10.1016/j.proeng.2015.07.016
dc.identifier.issn1877-7058
dc.identifier.urihttp://hdl.handle.net/10400.8/15054
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationStrategic Project - UI 211 - 2011-2012
dc.relationStrategic Project - UI 4044 - 2011-2012
dc.relationSkeletal muscle regeneration through the application of cellular therapies and biomaterials - Translation to the veterinary practicealterado para:Cell-based Therapies in Regenerative Medicine – Thetherapeuthic potential of Umbilical Cord and Dental Pulp derived Stem/ Stromal Cells
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S1877705815012576
dc.relation.ispartofProcedia Engineering
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectnerve regeneration
dc.subjectneurogenic muscle atrophy
dc.subjectmesenchymal stem cells
dc.subjectumbilical cord
dc.subjectWharton´s jelly
dc.subjectfunctional assessment
dc.subjecthistomorphometry
dc.titleNeuro-muscular Regeneration Using Scaffolds with Mesenchymal Stem Cells (MSCs) Isolated from Human Umbilical Cord Wharton's Jelly: Functional and Morphological Analysis Using Rat Sciatic Nerve Neurotmesis Injury Modeleng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 211 - 2011-2012
oaire.awardTitleStrategic Project - UI 4044 - 2011-2012
oaire.awardTitleSkeletal muscle regeneration through the application of cellular therapies and biomaterials - Translation to the veterinary practicealterado para:Cell-based Therapies in Regenerative Medicine – Thetherapeuthic potential of Umbilical Cord and Dental Pulp derived Stem/ Stromal Cells
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0211%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FEME%2FUI4044%2F2011/PT
oaire.awardURIhttp://hdl.handle.net/10400.8/14319
oaire.citation.endPage113
oaire.citation.startPage106
oaire.citation.titleProcedia Engineering
oaire.citation.volume110
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameCaseiro Santos
person.givenNameAna Rita
person.identifier.orcid0000-0002-1143-2461
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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