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CBmeter- a new medical device for early screening of metabolic diseases
Publication . Guarino, Maria Pedro; Brito, Gabriel; Lages, Marlene; Fonseca-Pinto, Rui; Lopes, Nuno Vieira
Type 2 diabetes mellitus (T2DM) is a highly prevalent disease worldwide which is asymptomatic in about 44% of patients being critical to search for new ways of early diagnosis. Recent studies have demonstrated that the etiology of this disease may be associated with alterations in the function of the carotid body (CB), a chemosensor organ located within the bifurcation of the carotid artery. In animal models of metabolic syndrome it was observed that the CBs are overactivated, underlying diseases such as obesity, hypertension and T2DM. This discovery provided a new paradigm in the neuroendocrinology field, suggesting that diagnostic function of the CBs has predictive value for the development of metabolic diseases. Despite this fact, it is not common in clinical practice to look at the CBs as organs associated with endocrine dysfunction and we believe this is probably due to the nonexistence of a user-friendly, portable medical device that diagnosis the function of the CBs.
Development of a mixed-meal that impacts carotid-body mediated cardiorespiratory and metabolic parameters - a pilot study
Publication . Frazão, Ana; Costa, Andreia; Teixeira, Bárbara; Santo, Marisa; Brito, Gabriel; Lages, Marlene; Lopes, Nuno Vieira; Fonseca-Pinto, Rui; Pereira, Cidália; Guarino, Maria Pedro
The carotid bodies (CB) have been recently implicated in the genesis of metabolic diseases in animal models. The CBs respond to circulating insulin to increase heart rate, respiratory rate and blood glucose levels. In humans, this mechanism is not well characterized.
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Funding agency
Fundação para a Ciência e a Tecnologia
Funding programme
9876 - Politécnicos
Funding Award Number
SAICT-POL/23278/2016