Percorrer por autor "Oliveira, Diana"
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- Cross-cultural adaptation process of the "Conversation Analysis Profile for People with Aphasia" to the Portuguese languagePublication . Ferreira, Mariana; Oliveira, Diana; Correia, Ana; Dixe, Maria dos Anjos; Pós de Mina, Sónia; Whitworth, AnneThe Conversation Analysis Profile for People with Aphasia (CAPPA) provides specific information about strengths and weaknesses of the communication between people with aphasia and their family caregiver within a conversational context. OBJECTIVE: The aim of this paper was to present the results of the first stages of cross-cultural adaptation of the CAPPA for the European Portuguese language. METHODS: This methodology study describes the translation and back-translation processes, following the recommended steps to that end. In addition, following the consent of one of the original authors, the process of content validation of the CAPPA commenced. The instrument was submitted for assessment before a panel of experts in the area, who constituted the population of this study. RESULTS: After the translation and back-translation processes, a panel of experts was convened to adapt the Delphi technique. Some questions were excluded on the basis of ambiguity, relevance and potential repetition. Suggestions made by the expert panel were included in a revised version of the tool. 159 items obtained a 100% consensus in relevance, and 157 items were considered suitable by the expert panel, validating the content of the instrument. CONCLUSION: The final version will now be applied to the target population in order to carry out the psychometric validation.
- Late-Night Salivary Cortisol: Cut-Off Definition and Diagnostic Accuracy for Cushing’s Syndrome in a Portuguese PopulationPublication . Lages, Adriana De Sousa; Oliveira, Diana; Paiva , Isabel; Oliveira, Patrícia; Rebelo-Marques, Alexandre; Carrilho, Francisco; Frade, João Gonçalo Leal de Oliveira e SilvaIntroduction: Diagnosis of Cushing’s syndrome remains a challenge in clinical endocrinology. Even though late-night salivary cortisol is used as screening tool, individualized cut-off levels for each population must be defined.Material and Methods: Three groups of subjects were studied: normal subjects, suspected and proven Cushing’s syndrome. Salivary cortisol was measured using an automated electrochemiluminescence assay. The functional sensitivity of the assay is 0.018 μg/dL. The diagnostic cut-off level was defined by Receiver Operating Characteristic curve and Youden’s J index.Results: We studied 127 subjects: 57 healthy volunteers, 39 patients with suspected and 31 with proven Cushing’s syndrome. 2.5th- 97.5th percentile of the late-night salivary cortisol concentrations in normal subjects was 0.054 to 0.1827 μg/dL. Receiver Operating Characteristic curve analysis showed an area under the curve of 0.9881 (p < 0.0001). A cut-off point of 0.1 μg/dL provided a sensitivity of 96.77% (95% CI 83.3 - 99.92%) and specificity of 91.23% (95% CI 80.7 - 97.09%). There was a significant correlation between late-night salivary cortisol and late-night serum cortisol (R = 0.6977; p < 0.0001) and urinary free cortisol (R = 0.5404; p = 0.0025) in proven Cushing’s syndrome group.Discussion: The mean ± SD late-night salivary cortisol concentration in patients with proven Cushing’s syndrome (0.6798 ± 0.52 μg/dL) was significantly higher (p < 0.0001). In our population, the late-night salivary cortisol cut-off was 0.1 μg/dL with high sensitivity and specificity.Conclusion: Late-night salivary cortisol has excellent diagnostic accuracy, making it a highly reliable, noninvasive, screening tool for outpatient assessment. Given its convenience and diagnostic accuracy, late-night salivary cortisol may be added to other traditional screening tests on hypercortisolism
- Rationale and design of long-term outcomes and vascular evaluation after successful coarctation of the aorta treatment studyPublication . Martins, Jose D.; Zachariah, Justin; Selamet Tierney, ElifSeda; Truong, Uyen; Morris, Shaine A.; Kutty, Shelby; de Ferranti, Sarah D.; Rhodes, Jonathan; Antonio, Marta; Guarino, Maria Pedro; Thomas, Boban; Oliveira, Diana; Gauvreau, Kimberlee; Jalles, Nuno; Geva, Tal; Carmo, Miguel; Prakash, AshwinCoarctation of the aorta (CoA) can be treated using surgery, balloon angioplasty, or stent implantation. Although short-term results are excellent with all three treatment modalities, long-term cardiovascular (CV) morbidity and mortality remain high, likely due to persistently abnormal vascular function. The effects of treatment modality on long-term vascular function remain uncharacterized. The goal of this study is to assess vascular function in this patient population for comparison among the treatment modalities.