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Additive manufactured Poly("-caprolactone)-graphene scaffolds: Lamellar crystal orientation, mechanical properties and biological performance

2022Journal article Open access
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dc.contributor.authorBiscaia, Sara
dc.contributor.authorSilva, João C.
dc.contributor.authorMoura, Carla
dc.contributor.authorViana, Tânia
dc.contributor.authorTojeira, Ana
dc.contributor.authorMitchell, Geoffrey R.
dc.contributor.authorPascoal-Faria, Paula
dc.contributor.authorFerreira, Frederico Castelo
dc.contributor.authorAlves, Nuno
dc.date.accessioned2023-02-27T15:35:22Z
dc.date.available2023-02-27T15:35:22Z
dc.date.issued2022
dc.description.abstractUnderstanding the mechano–biological coupling mechanisms of biomaterials for tissue engineering is of major importance to assure proper scaffold performance in situ. Therefore, it is of paramount importance to establish correlations between biomaterials, their processing conditions, and their mechanical behaviour, as well as their biological performance. With this work, it was possible to infer a correlation between the addition of graphene nanoparticles (GPN) in a concentration of 0.25, 0.5, and 0.75% (w/w) (GPN0.25, GPN0.5, and GPN0.75, respectively) in three-dimensional poly("-caprolactone) (PCL)-based scaffolds, the extrusion-based processing parameters, and the lamellar crystal orientation through small-angle X-ray scattering experiments of extruded samples of PCL and PCL/GPN. Results revealed a significant impact on the scaffold’s mechanical properties to a maximum of 0.5% of GPN content, with a significant improvement in the compressive modulus of 59 MPa to 93 MPa. In vitro cell culture experiments showed the scaffold’s ability to support the adhesion and proliferation of L929 fibroblasts (fold increase of 28, 22, 23, and 13 at day 13 (in relation to day 1) for PCL, GPN0.25, GPN0.5, and GPN0.75, respectively) and bone marrow mesenchymal stem/stromal cells (seven-fold increase for all sample groups at day 21 in relation to day 1). Moreover, the cells maintained high viability, regular morphology, and migration capacity in all the different experimental groups, assuring the potential of PCL/GPN scaffolds for tissue engineering (TE) applications.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBiscaia, S.; Silva, J.C.; Moura, C.; Viana, T.; Tojeira, A.; Mitchell, G.R.; Pascoal-Faria, P.; Ferreira, F.C.; Alves, N. Additive Manufactured Poly("-caprolactone)-graphene Scaffolds: Lamellar Crystal Orientation, Mechanical Properties and Biological Performance. Polymers 2022, 14, 1669. https://doi.org/ 10.3390/polym14091669pt_PT
dc.identifier.doi10.3390/polym14091669pt_PT
dc.identifier.issn2073-4360
dc.identifier.urihttp://hdl.handle.net/10400.8/8163
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationUID/BIO/04565/2020pt_PT
dc.relationCentre for Rapid and Sustainable Product Development
dc.relationLA/P/0140/2020pt_PT
dc.relationCentre for Rapid and Sustainable Product Development
dc.relationPAMI-ROTEIRO/0328/2013pt_PT
dc.relationCENTRO-01-0145-FEDER-000014-3362pt_PT
dc.relationIn silico models guiding in vitro biophysical stimulation of biomimetic hierarchical scaffolds: a computational modelling approach towards functional osteochondral regeneration
dc.relation.publisherversionhttps://www.mdpi.com/2073-4360/14/9/1669pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAdditive manufacturingpt_PT
dc.subjectGraphenept_PT
dc.subjectLamellar crystal orientationpt_PT
dc.subjectMechanical propertiespt_PT
dc.subjectPoly("-caprolactone)pt_PT
dc.subjectTissue engineeringpt_PT
dc.titleAdditive manufactured Poly("-caprolactone)-graphene scaffolds: Lamellar crystal orientation, mechanical properties and biological performancept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for Rapid and Sustainable Product Development
oaire.awardTitleCentre for Rapid and Sustainable Product Development
oaire.awardTitleIn silico models guiding in vitro biophysical stimulation of biomimetic hierarchical scaffolds: a computational modelling approach towards functional osteochondral regeneration
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04044%2F2020/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FEME-SIS%2F0838%2F2021/PT
oaire.citation.issue9pt_PT
oaire.citation.titlePolymerspt_PT
oaire.citation.volume14pt_PT
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oaire.fundingStream9471 - RIDTI
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person.familyNameBiscaia
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person.givenNameSara
person.givenNameJoão Carlos
person.givenNameCarla Sofia
person.givenNameTânia
person.givenNameAna
person.givenNameGeoffrey
person.givenNamePaula
person.givenNameFrederico Castelo
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rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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