Viana, T.Biscaia, S.Dabrowska, E.Franco, M.Carreira, P.Morouço, P.Alves, N.2023-02-172023-02-172019-04-09Viana, T., Biscaia, S., Dabrowska, E., Franco, M. C., Carreira, P., Morouço, P., & Alves, N. (2019). A Novel Biomanufacturing System to Produce Multi-Material Scaffolds for Tissue Engineering: Concept and Preliminary Results. Applied Mechanics and Materials, 890, 283–289. https://doi.org/10.4028/www.scientific.net/amm.890.2831662-7482http://hdl.handle.net/10400.8/8149This research work aims to validate a new system that enables the fabrication of multimaterial 3D structures using poly(e-caprolactone) and sodium alginate for potential use in Tissue Engineering applications. To produce multi-material scaffolds for Tissue Engineering, accurate techniques are needed to obtain three-dimensional constructs with clinically appropriate size and structural integrity. This paper presents a novel biomanufacturing system which can fabricate 3D scaffolds with precise shape and porosity, through the control of all fabrication modules by an integrated computational platform. The incorporation of a clean flow unit and a camera makes it possible to produce scaffolds in a clean environment and provides a monitoring tool to analyse constructs during the production, respectively.engTissue engineeringBiomanufacturingBioprintingMicro-extrusionHeterogenous Scaffoldsjournal article10.4028/www.scientific.net/AMM.890.283