Dias, J.R.Baptista-Silva, S.Sousa, A.Oliveira, A. L.Bártolo, P. J.Granja, P. L.2023-05-312023-05-312018-08Dias, J. R., Baptista-Silva, S., Sousa, A., Oliveira, A. L., Bártolo, P. J., & Granja, P. L. (2018). Biomechanical performance of hybrid electrospun structures for skin regeneration. Materials Science and Engineering C, 93, 816–827. https://doi.org/10.1016/j.msec.2018.08.0500928-49311873-0191http://hdl.handle.net/10400.8/8541This study was supported by the Projects PTDC/BBB-ECT/2145/ 2014 and UID/Multi/04044/2013, financed by European Regional Development Fund (ERDF) through the Portuguese national programs Programa Operacional Factores de Competitividade (COMPETE), Portugal2020 and Norte2020, and by Portuguese funds through Fundação para a Ciência e a Tecnologia (FCT). This work is also supported by the research grants SFRH/BD/91104/2012 awarded to Juliana Dias and SFRH/BPD/90047/2012 awarded to Aureliana Sousa by FCT, and by the Investigator FCT program IF/00411/2013, awarded to Ana L. Oliveira. The authors thanks to CEMUP, University of Porto for the SEM images.Wound dressings made by electrospun nanofibers have been demonstrating great potential to regenerate skin tissue as compared to the conventional membrane products available in the market. Until today most of the developed dressings have only demonstrated the capability to regenerate the dermis or epidermis. In this study we propose new hybrid electrospun meshes combining polycaprolactone and gelatin. Several approaches, multilayer, coating and blend were stablished to investigate the most appropriate hybrid structure with potential to promote skin regeneration in its full thickness. The structures were evaluated in terms of physico-chemical properties (porosity, water vapor permeability, contact angle and swelling degree) and according to its mechanical and biological performance. Multilayer and blend structures demonstrated to fit most of native skin requirements. However, looking to all the performed characterization we considered multilayer as the most promising hybrid structures, due its high porosity which contributed to an ideal water vapor permeability rate and good mechanical and biological properties. Based on this multilayer structure is a promisor wound dressing.engHybrid structuresElectrospun meshesWound dressingsECMSkin regenerationjournal article10.1016/j.msec.2018.08.050