Violante, CristianaLagoa, RicardoMarques-da-Silva, Dorinda2026-03-162026-03-162022-07-21Violante, C., Lagoa, R., & Marques-da-Silva, D. (2022). Promotion of Dermal Permeation of Bioactive Compounds Using a Microneedle Device. Medical Sciences Forum, 11(1), 4. https://doi.org/10.3390/BiTaP-12840http://hdl.handle.net/10400.8/15878Article number - 4This article belongs to the Proceedings of Biosystems in Toxicology and Pharmacology—Current Challenges.Presented at the Biosystems in Toxicology and Pharmacology — Current challenges, 8–9 September 2022, Online; Available online: https://bitap.sciforum.net/Several natural bioactive compounds are described for their beneficial effects to skin. Nevertheless, for some compounds, dermal absorption is a challenge, demanding new methods to enhance skin penetration. In this work, pre-treatment with a microneedle device was tested to promote the permeation of caffeine and epicatechin through ex vivo pig skin. The results indicated that the microneedle pre-treatment increased the permeation of both compounds at a similar range. Compared to untreated skin, more than 20% higher amounts of caffeine and epicatechin crossed the treated skin. The data support the application of microneedle systems to promote the dermal delivery of bioactive compounds.engbioactive compoundscaffeineepicatechinskin permeationmicroneedlesconference paper10.3390/bitap-128402673-9992