Crozet, PierreMargalha, LeonorConfraria, AnaRodrigues, AméricoMartinho, CláudiaAdamo, MattiaElias, Carlos A.Baena-Gonzalez, Elena2026-06-092026-06-092014-05-20Rodrigues, A., Adamo, M., Margalha, L., Baena-González, E., Crozet, P., Confraria, A., Elias, C. A., & Martinho, C. (2014). Mechanisms of regulation of SNF1/AMPK/SnRK1 protein kinases. Frontiers in Plant Science, 5, 190. https://doi.org/10.3389/fpls.2014.001901664-462Xhttp://hdl.handle.net/10400.8/16389TheSNF1(sucrosenon-fermenting1)-relatedproteinkinases1(SnRKs1)aretheplantorthologsofthebuddingyeastSNF1andmammalianAMPK(AMP- activatedproteinkinase).Theseevolutionarilyconservedkinasesaremetabolicsensorsthatundergoactivationinresponsetodecliningenergylevels.Uponactivation,SNF1/AMPK/SnRK1kinasestriggeravasttranscriptionalandmetabolicreprogramingthatrestoresenergyhomeostasisandpromotestolerancetoadverseconditions,partlythroughaninductionofcatabolicprocessesandageneralrepressionofanabolism.Thesekinasestypicallyfunctionasaheterotrimericcomplexcomposedoftworegulatorysubunits,βandγ,andanα-catalyticsubunit,whichrequiresphosphorylationofaconservedactivationloopresidueforactivity.Additionally,SNF1/AMPK/SnRK1kinasesarecontrolledbymultiplemechanismsthathaveanimpactonkinaseactivity,stability,and/orsubcellularlocalization.HerewewillreviewcurrentknowledgeontheregulationofSNF1/AMPK/SnRK1byupstreamcomponents,post-translationalmodifications,variousmetabolites,hormones,andothers,inanattempttohighlightboththecommonalitiesoftheseessentialeukaryotickinasesandthedivergencesthathaveevolvedtocopewiththeparticularitiesofeachoneofthesesystems.engSnRK1SNF1AMPKStressEnergy signalingArabidopsisKinase regulationjournal article10.3389/fpls.2014.00190