Horta, AndréAlves, CelsoPinteus, SusetePedrosa, Rui2025-07-082025-07-082015-03-23Horta, A., Alves, C., Pinteus, S. and Pedrosa, R. (2015). The marine origin of drugs. In Phycotoxins (eds L.M. Botana and A. Alfonso). https://doi.org/10.1002/9781118500354.ch1397811185003619781118500354http://hdl.handle.net/10400.8/13579Chapter 13: The marine origin of drugs (Pages: 293-316):Outstanding research work has been done in the last 50 years, resulting in the increase of knowledge related to marine organisms as producers of high value-added biomolecules. This chapter highlights some of the main topics related with marine drug origin, with a particular emphasis on the unique marine chemical ecology environmental as critical conditions for marine drug production. Additionally, some of the most relevant marine drug success stories associated to their therapeutic use, or as research pharmacology tools, is also described, including marine toxin drugs (e.g. tetradotoxin, okadaic acid, Cytarabine, Eribulin mesylate and Ziconotide). The marine drug origin of the FDA-approved drugs, as well all the marine compounds under clinical trials evaluations (phases III, II and I), are the main targets of this chapter.engChemical ecologyCytarabineEribulinMarine bacteriaOkadaic acidTetrodotoxinZiconotidebook part10.1002/9781118500354.ch13