Duarte, Ana M.Guarino, Maria P.Barroso, SoniaGil, Maria M2020-08-172020-08-172020Duarte, A.M.; Guarino, M.P.; Barroso, S.; Gil, M.M. Phytopharmacological Strategies in the Management of Type 2 Diabetes Mellitus. Foods 2020, 9, 271.2304-8158http://hdl.handle.net/10400.8/5086The authors thank FCT, Portugal, for financial support (UID/MAR/04292/2019). This work was also supported by project SmartBioR (CENTRO-01-0145-FEDER-000018, Integrated Programme SR&TD co-funded by Centro 2020 program, Portugal 2020, European Union, through the European Regional Development Fund).Type 2 Diabetes Mellitus (T2DM) is a chronic disease which corresponds to 90% of the worldwide cases of diabetes, mainly due to epigenetic factors such as unhealthy lifestyles. First line therapeutic approaches are based on lifestyle changes, most of the time complemented with medication mostly associated with several side e ects and high costs. As a result, the scientific community is constantly working for the discovery and development of natural therapeutic strategies that provide lower financial impact and minimize side e ects. This review focus on these nature-based therapeutic strategies for prevention and control of T2DM, with a special emphasis on natural compounds that present pharmacological activity as dipeptidyl peptidase-4 (DPP4), alpha-amylase, alpha-glucosidase, lipase, and protein tyrosine phosphatase 1B (PTP1B) inhibitors.engType 2 diabetes mellitusPhytopharmacologyDipeptidyl peptidase-4 (DPP4)Alpha-amylaseAlpha-glucosidaseLipaseProtein tyrosine phosphatase 1B (PTP1B)journal article10.3390/foods9030271