Ribeiro, Helena FiatsPelloso, Fernando CastilhoFonseca, Beatriz Sousa daCamparoto, Camila WohlenbergCarvalho, Maria Dalva de BarrosMarques, Vlaudimir DiasBitencourt, Mariá RomanioStevanato, Kely PavianiBorba, Pedro BeraldoBorghesan, Deise Helena PellosoEgger, Paulo AcácioAlarcão, Ana Carolina JacintoCuman, Roberto Kenji NakamuraHuber, Isabella Morais TavaresConsolaro, Márcia Edilaine LopesPujals, ConstanzaLaranjeira, CarlosPedroso, Raíssa BocchiPelloso, Sandra Marisa2025-07-312025-07-312025-05-13Ribeiro, H.F.; Pelloso, F.C.; Fonseca, B.S.d.; Camparoto, C.W.; Carvalho, M.D.d.B.; Marques, V.D.; Bitencourt, M.R.; Stevanato, K.P.; Borba, P.B.; Borghesan, D.H.P.; et al. Racial and Socioeconomic Disparity in Breast Cancer Mortality: A Systematic Review and Meta-Analysis. Cancers 2025, 17, 1641. https://doi.org/ 10.3390/cancers171016412072-6694http://hdl.handle.net/10400.8/13820Article number - 1641This article belongs to the Special Issue Socio-Demographic Factors and Cancer ResearchBackground/Objectives: Breast cancer is one of the leading causes of female mortality worldwide, but significant racial and socioeconomic disparities persist in disease outcomes. This review aimed to analyze racial and socioeconomic inequalities in mortality and survival from breast cancer, identifying the impact of social risk factors on access to diagnosis and treatment. Methods: A systematic literature review and meta-analysis was performed following PRISMA guidelines. Eighteen studies published between 2014 and 2024 were included, with 11 contributing to the meta-analysis. Random-effect models were used to assess correlations between socioeconomic status, race, and clinical outcomes, including heterogeneity and publication bias analyses. Results: The strongest associations were observed between income, race, and breast cancer survival, with survival significantly worse among Black women and low-income populations (p < 0.001). Income also showed a strong positive correlation with clinical outcomes. In contrast, the overall effect on mortality was not statistically significant (p = 0.290), likely due to high heterogeneity across studies (I2 = 100%). These findings suggest that structural disparities in access to healthcare and early detection substantially affect survival rates. Conclusions: Racial and socioeconomic disparities in breast cancer outcomes remain critical public health challenges. Targeted policies to expand early diagnosis and ensure equitable access to effective treatment are essential to reduce these disparities and improve survival in underserved populations.engSocioeconomic disparityCulture-specific cancer outcomesBreast cancerjournal article10.3390/cancers17101641