Caseiro, A.R.Pereira, T.Bártolo, P. J.Santos, J.D.Luís, A.L.Maurício, A.C.2025-10-282025-10-282015A.R. Caseiro, T. Pereira, P.J. Bártolo, J.D. Santos, A.L. Luís, A.C. Maurício, Mesenchymal Stem Cells and Biomaterials Systems – Perspectives for Skeletal Muscle Tissue Repair and Regeneration, Procedia Engineering, Volume 110,2015, Pages 90-97, ISSN 1877-7058, https://doi.org/10.1016/j.proeng.2015.07.014.1877-7058http://hdl.handle.net/10400.8/14409Conference name 4th International Conference on Tissue Engineering - An ECCOMAS Thematic Conference, ICTE 2015Conference date 25 June 2015 - 27 June 2015Conference city Lisboa, PortugalSkeletal muscle is essential in voluntary movement and other major vital functions. Muscle injuries are important in clinical practice and, despite skeletal muscle's good regenerative ability, severe tissue loss impairs complete myofibre regeneration, limiting structural and functional recovery of the affected muscle, eventually leading to the development of non-contractile fibrous scar. The intrinsic healing mechanisms rely in great extent on the residing progenitor population but significant drawbacks to their practical application in regenerative strategies boosted the search for alternative cell sources, such as extra-fetal mesenchymal stem cells (MSCs). MSCs have demonstrated to positively influence the regeneration of different disease models. When severe volumetric muscle tissue loss occurs, the body is seldom capable of replacing the lost portions with fully functional tissue. A rational strategy to aid the healing of such situations is the application of biomaterial implants that provide a structural matrix for the ingrowth of regenerating muscle fibres. Both synthetic and natural biomaterials have been hypothesized for this purpose and some have reached as far clinical cases applications. Obvious improvements are observed in most cases, but reaction to some biomaterials and functional recovery are still a challenge. The addition of MSCs to the biomaterials seems to improve the systems' performance in the overall regenerative milieu. This strategies promote scaffold's vascularization and integration, as well as accelerated tissue ingrowth and reduces scar formation, resulting in improved recovery rates at both structural and functional levels.engBiomaterialsDental pulpMesenchymal stem cellsSecretomeSkeletal muscleUmbilical cordWharton's jellyjournal article10.1016/j.proeng.2015.07.014