Quesada, AlbertoUgarte-Ruiz, MaríaIglesias, M. RocíoPorrero, M. ConcepciónMartínez, RemigioFlorez-Cuadrado, DiegoCampos, Maria J.García, MaríaPíriz, SegundoSáez, José LuisDomínguez, Lucas2025-06-062025-06-062016-04Quesada A, Ugarte-Ruiz M, Iglesias MR, Porrero MC, Martínez R, Florez-Cuadrado D, Campos MJ, García M, Píriz S, Sáez JL, Domínguez L. Detection of plasmid mediated colistin resistance (MCR-1) in Escherichia coli and Salmonella enterica isolated from poultry and swine in Spain. Res Vet Sci. 2016 Apr;105:134-5. doi: 10.1016/j.rvsc.2016.02.0030034-5288http://hdl.handle.net/10400.8/13170Recent findings suggest that use of colistin as a last resort antibiotic is seriously threatened by the rise of a new plasmid mediated mechanism of resistance (MCR-1). This work identifies, for the first time in Southern Europe, the gene mcr-1 in nine strains from farm animals (poultry and swine) corresponding to five Escherichia coli and four Salmonella enterica, amongwhich three belong to serovar Typhimuriumand one to Rissen. TheMCR-1 was found encoded by a plasmid highly mobilizable by conjugation to the E. coli J53 strain. Two E. coli strains carried two determinants, mcr-1 plus pmrA or pmrB mutations, known to confer colistin resistance.engColistin resistancemcr-1PmrABPlasmidS. entericaE. colijournal article10.1016/j.rvsc.2016.02.003