Rodrigues, Lídia Maria LourençönLima, Inacia Bezerra deSantos, Luiz Ricardo Albano dosBollela, Valdes RobertoCruz-Cunha, Maria ManuelaRijo, Rui, Rui Pedro Charters LopesAlves, Domingos2025-07-162025-07-162018-10-23Lídia Maria Lourençön Rodrigues, Inacia Bezerra de Lima, Luiz Ricardo Albano dos Santos, Valdes Roberto Bollela, Maria Manuela Cruz-Cunha, Rui Pedro Charters Lopes Rijo, Domingos Alves, Towards a standardized protocol for conducting randomized clinical trial for software, Procedia Computer Science, Volume 138, 2018, Pages 125-130, ISSN 1877-0509, https://doi.org/10.1016/j.procs.2018.10.018.1877-0509http://hdl.handle.net/10400.8/13680In the last decade, evidence-based medical practice has been aided on a large scale by computerized decision support tools, aimed at reducing diagnostic and therapeutic uncertainty, complementing the actions of the health professional. With the technological evolution, it is already possible to consider these systems as part of the clinical intervention, both for the diagnostic stage and for the treatment of diseases. This article proposes the creation of a specific clinical trial protocol to evaluate the effects of the software as clinical intervention in different medical settings. The proposal is unprecedented and extremely relevant in the scientific literature and able to standardize from the development stage to the application of the software aiding in the treatment of diseases.engclinical protocolclinical trial for softwareevidence-based medicinejournal article10.1016/j.procs.2018.10.018