Campos, Maria JorgePalomo, GonzaloHormeño, LorenaUgarte, MaríaPorrero, María ConcepciónHerrera-León, SilviaVadillo, SantiagoPíriz, SegundoQuesada, Alberto2026-04-092026-04-092013-10Campos, M. J., Palomo, G., Hormeno, L., Ugarte, M., Porrero, M. C., Herrera-León, S., ... & Quesada, A. (2013). Co-occurrence of ACSSuT and cephalosporin resistance phenotypes is mediated by int1-associated elements in nontyphoidal Salmonella enterica from human infections in Spain. Microbial Drug Resistance, 19(5), 384-391.1076-62941931-8448http://hdl.handle.net/10400.8/16079A screening of antimicrobial resistance and its genetic determinants has been performed on 300 Salmonella enterica isolates collected during 2004-2008 from human infections in Spain. Salmonella Typhimurium and Salmonella Enteritidis were the major serotypes, which were found with similar frequencies covering 80% of the bacterial collection. Salmonella Typhimurium isolates frequently shared low susceptibility to antimicrobials of the penta-resistance phenotype (ACSSuT) and/or cephalosporin resistance. The ACSSuT profile was found closely linked to int1-associated gene cassettes, with major elements carrying DNA fragments of 1.0 Kb (aadA2 gene) plus 1.2 Kb (blaPSE-1 gene) or 2.0 Kb (aadA1 and blaOXA-1 genes). Among these, ACSSuT and cephalosporin resistances were associated in Salmonella Typhimurium isolates expressing the blaOXA gene. β-lactamase activities were also detected from isolates carrying blaTEM, blaCMY, or blaSHV, although only the two last genes expressed extended-spectrum β-lactamases. The clonal analysis of S. enterica strains suggests that both horizontal and vertical transfer mechanisms are involved in the wide dissemination of their antimicrobial resistance.engAnti-Bacterial AgentsBeta-LactamasesCephalosporin ResistanceCephalosporinsjournal article10.1089/mdr.2012.0261