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Title: Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteins
Author: Park, Sang-Youl
Fung, Pauline
Nishimura, Noriyuki
Jensen, Davin R.
Fujii, Hiroaki
Zhao, Yang
Lumba, Shelley
Santiago, Julia
Rodrigues, Américo
Chow, Tsz-fung F.
Alfred, Simon E.
Bonetta, Dario
Finkelstein, Ruth
Provart, Nicholas J.
Desveaux, Darrell
Rodriguez, Pedro L.
McCourt, Peter
Zhu, Jian-Kang
Schroeder, Julian I.
Volkman, Brian F.
Cutler, Sean R.
Keywords: Abscisic acid
Type 2C protein phosphatases
Issue Date: May-2009
Citation: PARK, Sang-Youl e outros - Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteins. Science. Vol. 324, n.º 5930 (2009), pp. 1068-1071.
Abstract: Type 2C protein phosphatases (PP2Cs) are vitally involved in abscisic acid (ABA) signaling. Here, we show that a synthetic growth inhibitor called pyrabactin functions as a selective ABA agonist. Pyrabactin acts through PYRABACTIN RESISTANCE 1 (PYR1), the founding member of a family of START proteins called PYR/PYLs, which are necessary for both pyrabactin and ABA signaling in vivo. We show that ABA binds to PYR1, which in turn binds to and inhibits PP2Cs. We conclude that PYR/PYLs are ABA receptors functioning at the apex of a negative regulatory pathway that controls ABA signaling by inhibiting PP2Cs. Our results illustrate the power of the chemical genetic approach for sidestepping genetic redundancy.
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Appears in Collections:Artigos em revistas internacionais

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